DECENTRALIZED MEDICINE #4: AT THE 13N LATITUDE WE NEED TO BAN FOLIC ACID SUPPLEMENTATION
Added 2024-06-13 07:08:36 +0000 UTCThere has been some recent news out about folate levels, sunlight and artificial light. Many people do not know folate is a photosynthetic chemical and it links dark skin (melanin) for natural folate protection.
We have clear evidence (Cite 1) that ultraviolet radiation affects directly in proportion to folate human blood. Seasonal cycles repeat annually and light stability is more common at low latitudes. Therefore, the amount of photosynthetic chemicals we use acts as a photosensitizer to our chromophore proteins. This has big implications inside the tropics. The percentage of low folate values increases in summer by almost 3.5 percent in comparison to winter. Moreover, geneder differences are huge. Overall folate levels are lower in men as compared to women, regardless of seasonality. This makes sense because of who has the children.
Vitamin B9 (Folate) was first extracted from spinach leaves in 1941. The term folate comes from the same root as foliage: green and leafy. Folates are vital: they accept carbon atoms and pass them on as needed as the fundamental basis for proper methylation. This implies that during summer months folate levels should be expected to be at their lowest levels NATURALLY.
Folate biology has a specific and tight seasonal control mechanism linked to light. This is not a food story at all
What if there is no seasonal or light controls in place?
Folate is often given to pregnant women to prevent spinal dysraphisms today. This is something pediatric neurosurgeons deal with and why I know a lot about them. The incidence of these conditions has dropped but it is has done at a COST. Why? but too much folate/folic acid causes cognitive haze and sleep difficulty and may cause neural migration problems in artificially lit environments. This should awaken you what I wrote in Quantum Engineering #45.. In North America, (CAN/USA) folic acid was added to all grains in 1996. This is only a few decades ago and we are seeing the transgenerational effects of this right now in our children's disease phenotypes.
In general, it does not appear that even large amounts of folic acid taken orally are acutely toxic in adults. However, given the fundamental role of folate levels in synthesizing nucleotides (including RNA and DNA) and in methylation reactions as a methyl donor, high levels may have inadvertent implications for proper methylation of DNA during times of rapid cell division, such as in prenatal development. You'd think the idea that adding folic acid to the food supply might have caused centralized medicine to expect unintended consequences. Few thought about, much less studied it. I have always been worried about this effect since I learned that B12 was a photoreceptor in humans. (slide from Vermont)
This idea has been speculated in research circles as early as 2005, and specifically speculated to be relevant for the increase in autism in 2011.
MOST PEOPLE WITH MTHFR DEFECTS ARE SUPERSENSITIVE TO LIGHT VARIATIONS
An early review of potential problems with mass folic acid supplementation of the food supply was undertaken by Lucock and Yates. Here, they noted that a drastic increase in folates could lead to a selection for the previously rare MTHFR genetic substitution of T for C at area 677 (MTHFR C677T), and that if folic acid is supplemented at doses above 400 mcg that unmetabolized folic acid will circulate in the blood supply at a level largely consistent with the excess dose. In 2005, Lucock and Yates noted that high levels of folic acid in the blood does not generally occur as a result of ingesting natural folates and that “no work has been done so far to evaluate the biological and genetic consequences of excess long term exposure” to these circulating folic acids on DNA/RNA biology. After that review, there were two separate findings of unexpected increases in asthma and breathing problems associated with folic acid use.
It now appears that we have clear data that excessive methyl donor transfer has significant epigenetic effects in humans. This work dovetailed with another review questioning the wisdom of mass folic acid supplementation published in 1996. Smith et al. pointed out that by supplementing the food supply; several hundred thousands of persons are exposed to greatly increased levels of folic acid. These authors noted that prior research had shown that expectant mothers with low vitamin B-12 (most vegans/vegetarians) AND high levels of folic acid were associated with offspring having an unexpected increased risk for insulin resistance and disease associated with this condition. This is worrisome when you know that blue light exposure does the same thing and more.
Troen et al. found that some women past childbearing age subjected to high folic acid supplementation may be at risk for reduced immune system functioning causing inflammatory autoimmune conditions to spike. This problem has gotten worse since I first looked into it in 2005.
Did you know mammals exhibit genomic instability under conditions of folate deficiency in the skin. Remmber your skin is a neuroectodermal derivative. A lack of folate adversely effects your skin's cellular capacity to handle UVR light. This is why so make pale gingers burn so fast. Moreover, did you know that optimizing folate levels in skin is beneficial in preventing or repairing the pro-carcinogenic effects of UVR exposure? Folate restriction by any modern excuse leads to rapid depletion of intracellular reduced folates resulting in S-phase growth arrest. Did you know this leads to ncreased levels of inherent DNA damage, and it causes increased uracil misincorporation into DNA. This is called a frame shift mutation and it is how light can cause transepigenetic signaling. This frameshift mutation will not cause a significant loss in overall cellular viability. It is how mammals adapt to changing seasonal light environments. Folate depleted keratinocytes can be sensitized toward UVR induced apoptosis. This changes the biophoton spectra emission from mtDNA and this displays a diminished capacity to remove DNA breaks. This allows for changes in phenotype. This occurs by photo and oxidative DNA alterations. Your dermatologist likes to call this damage, but Mother Nature uses this for seasonal adaptation in your skin. When this occurs more UVR = more melanin production. This protects your folate stores from degrading. Nature is amazing when you see her recipes. Dermatolgyis dangerous because they do not understand what she is doing on your behalf. Thus, folate deficiency creates a "permissive environment for genomic instability to allow for seasonal change. It is not an early event in the process of skin carcinogenesis or autism. If one abuses the use of folic acid and blue light than you can and will get diseases. The effects of folate restriction, even in severely depleted, growth-arrested keratinocytes, were reversible by repletion with folate foods. In summertime, foods with folate are plentiful in the tropics for this reason. Photosynethesis always has our cells backs.
FOLIC ACID SUPPLEMENTS EXACERBATE MTHFR DEFECTS
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme encoded by the MTHFR gene and has significant implications in the field of decentralized medicine. This enzyme plays a critical role in the folate metabolism pathway, which is integral for processes like DNA synthesis and repair, as well as epigenetic alterations via methylation by light variation. Variants of the MTHFR gene are associated with altered enzyme activity, which can, in turn, affect mtDNA heteroplasmy and disease phenotypes. This happens by alterations created in the spectra of biophotons made via metabolism. You'll hear more about that soon enough.
Increased consumption of folic acid is prevalent in our modern world, and has negative consequences for MTHFR patients.. The effects of folic acid on the liver, the primary organ for folate metabolism, are now being unfolded. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions.
New data now suggests that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTHFR deficiency in the liver and skin of mammals. This deficiency results in hepatocyte and keritinocyte degeneration in both organs, suggesting a 2-hit mechanism whereby mutant hepatocytes cannot accommodate the lipid disturbances (how fatty acid carbon lenghts are dealt with and how melanin operates in the skin) and altered membrane integrity arising from changes in phospholipid/lipid metabolism. People forget the skin biology needs optimal light to control the lipid rafts in the skin as seasons change. Folic acid destroys this ability. This data has clinical implications for individuals consuming high-dose folic acid supplements, particularly those who are MTHFR deficient.
WHAT ABOUT CYP VARIANTS?
CYP enzymes are heme based and subject to blue light toxicity. They have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, archaea, and even in viruses. This is why so many astronauts have viral particles in the blood and space is known to foster cataracts and protein folding issues in the eye. However, they are not omnipresent in all bacteria; So space blood infections vary compared to the ones we see on Earth. More than 50,000 distinct CYP proteins are known to man.
Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen). Remember electrons must be excited by sunlight to use the photoelectric effect in the photon traps in aromatic amino acids. Based on the nature of the electron transfer proteins, CYPs can be classified into several groups: I covered this with Rohan during a past Sunday Q & A that lasted 5 hours. Members should listen back to those recorded Q & As to refresh their minds.
Microsomal P450 systems, in which electrons are transferred from NADPH via cytochrome P450 reductase (variously CPR, POR, or CYPOR). Cytochrome b5 (cyb5) can also contribute to reducing power to this system after being reduced by cytochrome b5 reductase (CYB5R).
Mitochondrial P450 systems, employ adrenodoxin reductase and adrenodoxin to transfer electrons from NADPH to P450.
Bacterial P450 systems, employ a ferredoxin reductase and a ferredoxin to transfer electrons to P450.
CYB5R/cyb5/P450 systems, in which both electrons required by the CYP come from cytochrome b5.
FMN/Fd/P450 systems, originally found in Rhodococcus species, in which an FMN-domain-containing reductase is fused to the CYP. (cytochrome 2 in humans is related to this system.
P450-only systems, which do not require external reducing power. Notable ones include thromboxane synthase (CYP5) for platelets, prostacyclin synthase (CYP8) for PG synthesis, and CYP74A (allene oxide synthase). You should begin to see just how we are beings of light who need solar programming by sunlight and not man-made light.
Anything transferring electrons to proteins = a semiconductive circuit. When you understand the photoelectric effect only works with photons and electrons you begin to see why SNP status are mostly superfluous and generally do not matter when you're in the sun chronically and you have melanin in your integument and interior properly renovated.
Melanin operates in us to charge separate water into its components of H+ and oxygen and 2 -4 electrons. The level of oxygen dissolved in cells is critical in varying the ultraweak biophoton signature from metaboilsm. Those two electrons liberated from charge separation obviate the need for exogenous and endogenous sources of electrons (grounding/food). SNPs evolved because mammals varying in how they ground and what they eat based on latitude and what photosynethesis can provide. SNPs and SAPs tell vary in how melanin biology is operating. They are like equalzer buttons for music made in cells.
People with a lack of melanin think SNPs matter way more than they do because functional medicine MDs tell them this. This is incorrect. Pale people without enough melanin lack electrons to run their semiconductive circuits. You'd be wise to avoid that level of centralized thinking in the future. Folic acid lowers electrons = lowers your redox power.
How humans operate is specific to humans and not to other mammals. Most of the BH4 and Vitamin C used as cofactors deliver electrons to the biochemicals. BH4 and Vitamin C deliver the exogenous sources. Melanin delivers the endogenous source of electrons. Humans create massive amounts of electrons when POMC is operational in their tissues. Here you see Noether's thereom show up yet again.
THE SUN IS THE BEST SOLUTION TO THIS PROBLEM
SUNLIGHT reduces all these risks, while modern lighting exacerbates it. Moreover, it appears nature is trying to tell us that the sun raises melanin and melanin is protective. Strong solar cycles in photosynthesis seem to simultaneously lower folate in foods in the summertime for a deep reason. That reason is epigenetic hypermethylation which can lead to sleep apnea and cancer formations later in life due to altered DNA methyl marking. This process also alters how RBC circadian cycles (ferrodoxin) can work within their circadian cycles with the innate immune system and TOLL receptors. Most people with anemias have this intrinsic problem linked to modern behaviors around light.
Folate is destroyed by strong sunlight with both UVA and UVC light. Darkened skin protects the stores we have, but there is now proof that folate levels are designed to be low when the solar radiation is strong in the local environment. These days most people are eating food humans have been engineered and/or genetically altered in some way. Then add in the effect of Artifiical light day and night. This throws off the normal variation of the natural folate cycle during seasons. Today, people in developed countries are getting MASSIVE amounts of folates in the form of folic acid. This is the real reason to avoid grains. Folates are now being ingested in three ways: as natural folates from food, as synthetic folic acid added to processed grains and synthetic from vitamin supplements. All of these idea are counter evolutionary to Nature's laws.
SUMMARY
Methylation patterns are linked to how light is transformed in a cell. When sunlight is absent for any reason mitochondrial redox drops. When this happens energy transformation drops. As a result of a lack of energy methylation problems shows up in both genomes. Decentralized clinicians know what to look for. Allopathic and function docs would know what to look for because they still have no idea that light controls the enzymatic flux in metabolic pathways.
Loss of mitochondrial redox power causes methylation problems to manifest in your labs without any SAP/SNP issues present in your MTHFR survey or nuclear genome. Very few clinicians know a lack of sunlight causes methylation defects.
It shows up in your labs in a very specific pattern of results as an accumulation of methionine and S-adenosylhomocysteine, with low or low-normal levels of S-adenosylmethionine (SAM) and homocysteine. PBM treatment fixes it. Sunlight is always the best treatment. Supplements not so good.
As a result of the supplementation of folic acid, the circulating level of unmetabolized folic acid, as well as total folates, has greatly increased over the past generation, probably to levels largely unprecedented in human history.
Folic acid has been shown to be able to epigenetically alter the functioning of the genome and to have long term effects on gene expression as I mentioned above.
The Centers for Disease Control Vaccine Safety Datalink data set compared children with autism to control children on several variables. Many people who think the link of vaccines to autism might be shocked to find out that folic acid supplementation during gestation is associated with a serious increased risk for autism. I believe the combination of artificial light and folic acid supplementation are causing neural migration problems. This is why parental melanin levels are important clues. This effect remains even when health-seeking behaviors and other variables are controlled. This is information parents of kids with AUTISM need to know. Autism, asthma, allergy, ectopy, eczema, diabetes T1D, T2D, and MODY, auto-immunity, and spinal abnormalities have their lowest incidence is lowest in equatorial environments and it appears now we know why this is the case. This is decentralized medicine 101 I will bring to El Salvador.
CITES
1. Valencia-Vera E, Aguilera J, Cobos A, Bernabó JL, Pérez-Valero V, Herrera-Ceballos E.. 'Association between seasonal serum folate levels and ultraviolet radiation'. 'J Photochem Photobiol B'. 2019 Jan;190:66-71
2. https://threadreaderapp.com/thread/1656714608793485326?refresh=1683832764
3. https://www.linkedin.com/article/edit/6330012027309875200/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/
5. https://en.rattibha.com/thread/1798513232203673687
Comments
May I suggest Dr. Hulda Clark's book, "The Cure for All Diseases" which I use in my Live Blood practice. Dr. Clark healed many with her research and I wish I had heard of her years ago. Briefly, seizures and migraines are both caused by microscopic parasites, and yes you can be born with them. She discusses the specific parasites, bacteria, solvents (poisons) in our environments and unsafe food sources every parent should know. 100% of my Live Blood clients have had parasites in their blood and easily clear them with Now brand Green Black Walnut w/Wormwood and Cloves tincture. Dr. Clark was instrumental in alleviating my back pain and migraines, so I am sharing with you.
CheyenneRN
2024-08-27 23:37:43 +0000 UTCThank you for this.. doctors need to become aware of this..
Christina Gior
2024-08-24 13:06:03 +0000 UTCDang I wish my dad had been more like you when it came to medicine and course correcting based on new information. Good work brother.
Abuelito
2024-07-17 14:37:41 +0000 UTCTiming of the exposure is a big factor. Your biology expects darkness at night. Exposing skin and eyes to light after dark in general is a bad move (even fire light presents a circadian disruption). Thus it's not only a blue light story. With that said, modern heavy exposure to primarily blue spectrum artificial light and screen backlighting omits the roughly 40% minimum red content present in sunlight throughout the day, something mammalian photoreception expects and needs to run its programs. Stacked onto this timing problem are the high frequency flicker rates LED lightbulbs use, meaning the "correct" spectrum might be present but the information reaching the body appears as if the continuous stream of stellar photons are being interrupted thousands of times every second. We don't notice such high rates consciously. Uncle Jack has some great blog posts here detailing the process by which artificial blue-heavy light affects your biology in far greater detail than I can parrot back. QT #10 is a good start One interesting tidbit I can recall is using several colors of light to perform a reflex test on the pupil in a clinical setting. A symptom of blue light toxicity is reduced pupillary constriction in response to that particular spectrum. As far as I know he hasn't detailed this process and hasn't endorsed non-clinicians using it. As for gauging your own status the best I can offer is tracking the symptoms that caused you to reach outside of the centralized medical system to this outspoken fellow: From adapting to a healthier lifestyle I noticed as I recovered I grew far more sensitive to light at night. I mostly use a dim red lantern for nighttime tasks as even red bulbs are too bright. I also noticed when forcing myself out of bed and outside in the morning that what was a vague feeling of "I'm now stuck up but I want to get back to sleep" became this burst of energy and enthusiasm for the day over the course of a few weeks. It feels like a sensory organ has been unlocked. As for activated charcoal I doubt it strictly because even if it preferentially absorbs deuterium over protium (no idea if it does) taken orally it doesn't penetrate the gut. The deuterium becomes an issue at the mitochondrial level. Fixing your mito colonies allows you to make your own DDW. Keep in mind that we adapted to the deuterium levels of our environment, deuterium has been in our water and food since we were prokaryotes. Most people who benefit from DDW need far greater lifestyle interventions than something akin to upgrading the bilge pump on a sinking ship. It's kind of like buying bagged air while refusing to take our heads out of the pool: We're battling upstream for "healthspans" and exotic herbal "biohacks" when there's a placid golden waterway sitting in the sky patiently waiting for us to come back and just look at it.
Abuelito
2024-07-17 03:04:29 +0000 UTCThank you abuelito! What is considered blue light toxic? How much time under it? How can we know?
Fatima Costalaurent
2024-07-16 20:32:32 +0000 UTCDr Jack, thanks for everything, you’ve made it all make more sense. I have 10 years of critical care experience as an RN and a major human health and optimization geek. I found out about MTHFR 2 years ago when my son had seizures at 5 months old. He had his first one right when he woke up in the morning and it was very short. I gave him vitamin D3 drops and we went to the Lake Michigan beach in February because I knew he needed sunlight for some reason inherently. ("now I know") He never seized at the beach, but as soon as we got back in my truck when the sun went down, he had seized 2 more times, very short after his feedings and a burp. It always happened after a burp I thought it was Sandifer Syndrome. When he woke up the next day he had a longer one and we took him to the hospital. The only thing I could think of was that earlier that week my mom gave him some oat meal for the first time but that was 2 days prior. My wife tiffany had her first migraine in about 2 years the night prior and day of my son's seizures. The night prior to his seizures we had cheated and ate a bunch of Pizza king that we usually don't do. She had a migraine one hour later, and my son had seizures after she breast fed him each time. When we got to the hospital he had another seizure so we got rushed back thankfully. There was no possible risk factor I could think of and the children's hospital in Indianapolis ran a clean MRI, clean blood work, he was checking their boxes for no risk factors. He didnt have a seizure for the rest of the day. I asked my wife to pump and dump her milk before feeding him to “flush out” the harmful ingredients in the pizza, (folic acids, phytic acids, wheat, corn, MSG etc). I contributed that to why he didn't have a seizure until she fed him at night in the hospital before pumping. He slept all night, she fed him in the morning without pumping, he seized. I explained this to the doctors and they did not listen, I asked if we could test his vitamin b6,9,12, vitamin d, copper, levels because I thought thats what we needed to know and they refused. They told us keppra for 2 years at least. From that moment I told my self I could never let someone else go through this system the without the right knowledge. Our holistic doctor helped us test him for what I originally asked for in the hospital and taught us about MTHFR. And tested us 4 which we all have the C variant. I got in touch with a ND about giving my son CBD, instead of keppra and that is what he’s on now. He is 21 months. Now I’ve been enlightened to exactly why my might be having seizures. He was born in fall when Vitamin D levels, we didn't prioritize cold exposure with our kids or getting the right light. I never took the toxic light serious enough until finding your work. Now everything about my wife's hashimotos, my AI, my son’s seizure, and other son's Iron Deficiency anemia makes sense from a very vague biophysics lens for me and I cannot unsee it in every patient I take care of. I am making so many new connections lately. Just wanted to share that somehow, thank you.
Austin Brewster
2024-07-14 20:50:31 +0000 UTChttps://x.com/DrJackKruse/status/1812138235750908392
Dr. Jack Kruse
2024-07-13 14:58:44 +0000 UTCActivated charcoal as an aid to deuterium depletion and other toxins?
Shelly Hilliard
2024-07-03 14:40:39 +0000 UTCThank you Abuelito. Great information and much appreciated. Congrats on your journey to health! I am a new website member and feel like I’m drinking from a firehouse - yet I love it. Learning so much while changing my life too.
Shelly Hilliard
2024-07-02 23:42:58 +0000 UTCUncle Jack answers questions with more detail for website members so I'll act as the human chatgpt and share what I've garnered from his podcast appearances. Sorry it doesn't fully answer your question but it covers a few super common supplement questions he gets: Many supplements are loaded with deuterium. For those suffering with mitochondrial issues that's not good. Slows the atphase rotor speed as heavy d with its extra neutron can't pass where the more common protium isotope can. Bad for heteroplasmy rates. Use of anything is unique to the patients circumstances. For example a liver cancer patient with a huge deuterium shadow on their liver mri taking a concentrated supplement when the desired substance is available at appropriate doses in a low deuterium food is counterproductive. On the flip side if you have a healthy redox then stuff like DDW is a waste of money as your mito colony is very capable of generating its own DDW to maintain shielding for proton tunneling in the mito membrane. Flipping it back, for some cancer types DDW can be beneficial as the affected tissues aren't producing protium efficiently. Uncle Jack has hammered in again and again that (save for specific circumstances) anything the body produces endogenously is not wise to use endogenously. Even if it helps Dave Asprey buy that new Benz. Melatonin and Vitamin D are oft used examples: D should be made from sunlight exposure to skin and eyes, if you're blue light toxic and can't raise your levels with sunlight then swallowing 10k iu a day is not solving the underlying POMC issue. It may reduce the symptoms that prompted you to get it checked, but your melanopsin is dying, free retinol is running amok and neolithic disease is en route to your precious tissues with friends and baseball bats. The tools offered in the leptin rx will help restore endogenous d production: cold water exposure to reduce band gap of semiconducting tissues (and thus reduce entropic losses), eating early in the day high-electron fare like seafood (oysters and cold water fish are ideal), full body exposure to sunrise (to sulfate collagen and other semiconductors) whilst harvesting free electrons using your sweat glands (make like the sphinx-all fours and face east) and plenty of uv sunlight (~10am to evening), gradually building up exposure times. Extreme cases may require moving to a lower latitude for some time to maximize sun exposure, particularly if you have a coupled haplotype optimized for equatorial living. On an old podcast I did hear Uncle Jack say that for extended intercontinental flights a low dose of melatonin was part of his protocol but (disclaimer) that was years ago so possibly no longer best practice based on whatever data he's been exposed to since and I can't recall the reasoning he gave. Anyway wish I could share more. I second your request and would also appreciate a breakdown of specific contexts where a supplement is appropriate in his paradigm. It seems he doesn't expend much time on them since the primary lever of health is an evolutionary correct relationship to the natural emf of our local star and home planet. Get that relationship right (and exclusive! going polyamorous with ALAN and nnemf will damage your biology) while simply eating stuff that grows in your latitude and you will likely never need any kind of supplement. I've been eating exclusively meat, fish and eggs for 8 months now and have never been healthier. Perfect bloodwork despite the limited diet, my fitzpatrick type 1 irish skin is tan and never burns and my energy is through the roof. I threw out my shelf of thorne crap. When I get a cut working outside I rub dirt in it and it heals faster than ointments and bandaids ever achieved. Often stagnant mud in old french drains. My friends know to cough on me when they get sick, because I just don't. From 305lb with cervical stenosis/melanoma at 20 to a 165lb athlete at 32. Uncle Jack has changed my life.
Abuelito
2024-07-02 23:32:17 +0000 UTCDr. Jack, what are your current recommendations regarding supplements? This question perhaps needs an entire blog to answer, yet as our knowledge evolves it’s imperative to circle back and update guidance about what vitamins/supplements are beneficial and those which are not ~ and please suggest brands if/as applicable. Thank you so very much for elevating our understanding of these magnificent magical bodies in which we live.
Shelly Hilliard
2024-06-25 21:23:31 +0000 UTCGreat blog post Jack!! I really need to come to El Salvador, everything going on down there is freaking awesome
Stian Van Zweden
2024-06-21 06:49:08 +0000 UTCUVR = UVradiation = VUV, UVC, UVB, UVA
Dr. Jack Kruse
2024-06-20 02:12:35 +0000 UTCDr. Kruse - You use the term "UVR" light several times above. Yet, I've not heard of this type of UV. Did you mean UV-IR? Please explain or expand?
cL34rC0mm
2024-06-17 14:42:15 +0000 UTCThe ultimate decentralized person for pregnancy would be a woman of course; try typing this in YouTube You're Not Anemic w/ Morley Robbins (youtube.com)- Lesha Nelson
michael john moreau
2024-06-16 15:51:57 +0000 UTCWonderful piece of writing. Last year, I fielded a phone call from an obstetrician who was upset that I told a patient to stop folate supplements due to an association with autism. Despite the fact that their guidelines say its important only for the first trimester. Yet another nutritional problem to address: In each Superselectos, there is a long aisle full of milk power "fortified" with vitamin A and D. I have never seen so much milk powder in my life. In my head, I could hear Jack saying vitamin A is horrible. And why on earth are they adding vitamin D to milk when the citizens have the ability to generate vitamin D all year with all that amazing sunlight.
DrM
2024-06-16 10:15:45 +0000 UTCMy simple mind is trying to connect the dots in sequential array. Line 4 in the summary paragraph "Decentralized clinicians know what to look for. Allopathic and function docs would [ NOT] (my inclusion) know what to look for because they still have no idea that light controls the enzymatic flux in metabolic pathways. Do I have that l line of thinking right.?
michael john moreau
2024-06-16 02:44:26 +0000 UTCWhat are your thoughts on Cerebral Folate Deficiency (CFD) and treating Autism kids with leucovorin to get more folate into the cerebral spinal fluid and into the brain? There are many stories of Autism reversal with this treatment.
Kyle
2024-06-14 04:00:19 +0000 UTCDr. Kruse - Thank you for your article. Although, the link to the cite #3. https://www.linkedin.com/article/edit/6330012027309875200/ GOES NOWHERE. Opens LinkedIn but does not reveal any article. Can you help with this? Cheers!
cL34rC0mm
2024-06-13 14:32:21 +0000 UTCUncle Jack, I guess you have many people after you because of different health conditions, I am trying to understand these concepts but I'm very limited due to the lack of knowledge in these subjects. My wife is a long-time anemic person, I assumed it was because of too much blue light and lack of sun (which is a norm in the Philippines not to take the sun). During our carnivore diet, her hemoglobin level went up to 90 (which was lower) in March. Her lips look more red, and she had more energy. We didn't have any info about the light back then so we didn't take the sun much. When we started to get the sun every morning, she had more energy. But now that we started to vary food because carnivore is too restricted, her blood level (hemoglobin) went down to 76. She looks pale again. Energy when down, despite the sun. Now, Philippines does not really have blue light blockers, so we received our glasses from Australia today. So we are hopeful that was a missing peace of our path to recovery. We felt lost, because we wanted to start having children, but her anemia is too strong, and I Got worried because we already lost a child (ectopic pregnancy) the first time. So, I put on a mission to heal her anemia first if possible but we don't understand why the hemoglobin go so down. I try to take the sun every morning, afternoon, and in sunset. I managed to make her take the morning sun at least. Anyway our doctor said to take folic acid, but now apparently that's a bad idea, this anemia thing is delaying our effort. If possible, what can we do? God Blees
Alejandro, Rosillon
2024-06-13 09:22:49 +0000 UTCThe brain does not do well at altitude. It stands in stark contrast to the heart. Hypoxia has progressive effects on the functioning of the central nervous system. Accidents that occur at extreme altitude on Everest and other mountains may be due to poor judgment as a consequence of hypoxic depression of cerebral function. More worrying is that these effects on cerebral function may be permanent. They mimic TBI insults. The American Medical Research Expedition to Everest studied its climbers a year after return to sea level and found some enduring abnormalities of cognitive function and ability to perform fast repetitive movements, although most functions tested had returned to pre-expedition values.
Dr. Jack Kruse
2024-06-13 08:29:10 +0000 UTCThe two organs with the most mitochondria show some interesting effects to consider for longevity and health. The heart works remarkably well at altitude. Initially there is an increase in cardiac output in relation to physical work but later this settles to sea level values. At all times there is increased heart rate and decreased stroke volume for a given level of work, though the maximum obtainable heart rate falls as higher altitudes are reached. The reason the heart adapts well at altitude I believe has a lot to do with UV and cold actions operating together in unison. Oxygen does not seem to tbe the main driver.
Dr. Jack Kruse
2024-06-13 08:27:13 +0000 UTCSince the percentage of oxygen in inspired air is constant at different altitudes, the fall in atmospheric pressure at higher altitude decreases the partial pressure of inspired oxygen and hence the driving pressure for gas exchange in the lungs. An ocean of air is present up to 9-10 000 m, where the troposphere ends and the stratosphere begins. The weight of air above us is responsible for the atmospheric pressure, which is normally about 100 kPa at sea level. This atmospheric pressure is the sum of the partial pressures of the constituent gases, oxygen and nitrogen, and also the partial pressure of water vapour (6.3 kPa at 37°C). As oxygen is 21% of dry air, the inspired oxygen pressure is 0.21×(100−6.3)=19.6 kPa at sea level. At sea level carbon dioxide is the main stimulus to ventilation in humans. At altitude hypoxia does increase ventilation, but usually only when the inspired oxygen pressure is reduced to about 13.3 kPa (3000 m altitude). At this inspired oxygen pressure the alveolar oxygen pressure is about 8 kPa, and with further increases in hypoxia ventilation rises exponentially. This hypoxic ventilatory response is mediated by the carotid body, and response varies widely among subjects. Interestingly, however, the ability to tolerate altitude does not seem to relate to the presence of a brisk hypoxic ventilatory response. Some climbers with poor hypoxic ventilatory response do particularly well—for example, Peter Habeler, who in 1978 became (with Rheinhold Messner) the first to climb Everest without oxygen. Why did Habeler have this ability? He is from Mayrhofen Austria. Mayrhofen is situated near the Hintertux glacier, which, at 3,250 metres (10,660 feet) above sea level, is above the snowline. This means Habeler was chronicly adapted to a high UV, low )2, and cold environment for most of his life before he attacked Everest without oxygen. In his town, skiing is available all year round. Mayrhofen sits between the Penken and the Ahorn mountains which provide ski runs in the winter and mountain biking, hiking and paragliding in the summer. It served as a teaching case for the situation I read about in the Monk Who Sold His Ferrari. This story was ciritical in my early understanding of the leptin melanocortin pathway.
Dr. Jack Kruse
2024-06-13 08:25:03 +0000 UTCAnaplerosis is the act of replenishing TCA cycle intermediates and cataplerosis is the term used for removal of TCA intermediates for biosynthesis. The spin cycle of the TCA is controlled by AM sunlight. How does the VDR receptor react to AM sunlight signaling? The VDR receptor inhibits cataplerosis and this should make sense. As you remove substrate from the main beta oxidative pathways you need to control the flux of electron flow in the inner mitochondrial membrane to put a cap on ROS/RNS and oxygen needs. Cataplerosis removes intermediates for biosynthesis in normal growth to which may be diverted from oxidative metabolism toward a biosynthetic fate, supporting cell growth. This process has no brake in cancer because the VDR receptor only operates with a base level of sulfated Vitamin D3. Without it, the VDR receptor is inactivated and this single factor alone supports high ECT, with inactivation of apoptosis which sets the tone for cancer. Today’s lesson is on the inverse relationship of UV light and oxygen in the lung of humans. This is a lesson in how ROS is tightly controlled by cells as ATP production rises. The real story is how the ultra weak biophoton release from mtDNA is optimized in this dance. There is deep lesson nature here that nature provides us but it remains hidden from centralized medicine. For every 1,000 meters (3,280ft) increase in altitude, there's a ~13% reduction in lung cancer incidence. Realize as you go higher you gain more UV exposure while simultaneously losing oxygen partial pressures to breath. The percentage of oxygen in inspired air is constant at different altitudes, the fall in atmospheric pressure at higher altitude decreases the partial pressure of inspired oxygen and hence the driving pressure for gas exchange in the lungs. When you compare someone living at 10,000ft vs sea level this is a MASSIVE difference. The data on light and oxygen shows us as a risk predictor of lung cancer incidence, elevation was second only to smoking prevalence. Atmospheric pressure and inspired oxygen pressure fall roughly linearly with altitude to be 50% of the sea level value at 5500 m and only 30% of the sea level value at 8900 m (the height of the summit of Everest). A fall in inspired oxygen pressure reduces the driving pressure for gas exchange in the lungs and in turn produces a cascade of effects right down to the level of the mitochondria, the final destination of the oxygen.
Dr. Jack Kruse
2024-06-13 08:01:00 +0000 UTCVery interesting. I wonder how riboflavin works in this context. Do you think riboflavin (cofactor of MTHFR) should be low in summer, so folate is more protected? Seems riboflavin is needed by the body, but probably in MTHFR during summer you want less? What do you think? Anyway I would also say that synthetic folic acid masks B12 deficiency by increasing cobalamin analogues in the blood, which probably mess up with light since cobalamins are photoreceptors.
Alessandro Carrese
2024-06-13 07:55:00 +0000 UTCAwesome blog Jack!
David Mc Gettigan
2024-06-13 07:49:44 +0000 UTC
