QUANTUM ENGINEERING #47: BIPOLAR DISORDER AND POMC

Today is the summer solstice and that is why this blog is being released today. More people with bipolar disorder will be admitted to ERs in the Northern Hemisphere today than any other day.  Now you are going to learn why this is the case.

Bipolar disorder (BD) is a chronic and common psychiatric pathology, which can be particularly disabling. The disease has a global prevalence rate of 1–4%, begins at an early age, i.e. predominantly between 15 and 25 years old, and persists throughout the life of patients. BD is characterized by a recurrence of mood depressive episodes (pathological decrease in mood and energy), hypomanic or manic episodes (pathological increase in mood and energy), or even mixed episodes (simultaneous presence of depressive and manic symptoms).

Bipolar disorder is a common mental condition in our modern world with a seasonal pattern of onset. In the spring, there is a higher incidence rate of mania or mixed onset and suicide associated with the equinox and solstice.  The reason for this is a defective pruning mechanism related to the cortisol melatonin cycle in cells.  The question is then what controls this pruning in us?

LINK

The pruning method of control in the brain is normally controlled by the cortisol melatonin cycle.  Cortisol usually creates new pathways and melatonin trims or prunes them to suit the environment the person is in.

In bipolar disorder, this system has gone awry.  Remember cortisol is controlled by light via ACTH and melatonin levels are made by the mitochondrial matrix.

Explain this to me like I am a 3rd grader Uncle Jack.

What if I told you it was because the FM radio station evolution built into your head went awry because the manner in which it works was usurped by your light choices? Would you believe that?

The FM receiver used by Mother Nature in our brain includes a clock that measures light and cavities filled with water. It turns out that the shape of things in our heads is prognostic on how good time our clocks tell. Imagine that. These two antennas use a phase-locked loop system that is also used in modern FM radio receivers in our car. Can you believe that? Because of its usefulness, the phase-locked loop is found in many wireless, radio, and general electronic items from mobile phones to broadcast radios, televisions to Wi-Fi routers, walkie-talkie radios to professional communications systems, and very much more.

Mother Nature built this FM radio station in the nervous system over 3 billion years ago. This is why brains first became important. Their original purpose was to inform cells of the seasonal connection between the sun and Earth. In turn, this data could be made useful to direct biological changes. This is how light changes the biochemistry inside of us. This is how we know it is summertime. In bipolar disorder, this system is awry when it is encumbered by too much mass in the antennae of the system.

What bends space/time in the universe? The masses associated with the matter in the universe do. Anything that has more mass than the smallest atom used inside of our molecular clocks changes how we experience time. Mass bends space/time!  Now ask yourself what magnetic fields do to space-time based on this picture below.

Magnetic fields tend to flatten and stiffen the fabric of space-time when masses are added to them and this alters our perception of seasons.

The circadian activity generated in the SCN clock of the eye needs to be transmitted to the rest of the brain in some way. It seems like the clock timing tract splits into two wires and informs the brain of what season it is. In Bipolar Disorder this is impossible because the eye clock is usually where the defect lies.  That defect in the antenna ruins the fidelity of the system and our brain cannot tell where the Earth and sun are in relation to one another. Pretty remarkable gadget Nature built in our heads. It appears the excess mass in the antenna screws up the connection of the FM radio station. Without a proper connection, the fidelity of the music coming from the system fails. That is what bipolar disease is to a metronome. Can you believe that? My friend the metronome says it's all true because of the physics of clock timing. It is apparently thrown off when we have too much weight (mass) in our clocks. Does something to the fabric of space-time deform magnetic fields? Wild decentralized stuff I tell you.

The 3rd-grade bipolar lesson is over.

BACK TO THE SCIENTIFIC EXPLANATION OF BIPOLAR DISEASE

These thymic episodes the bipolar patient experiences are interspersed with phases of clinical remission, known as “euthymic” episodes. The disease is associated with a high morbidity and mortality rate and due to the significant functional impact it induces, including during euthymic periods, BD is the cause of poor quality of life and is one of the ten most disabling diseases according to the World Health Organization. The diagnosis of BD is mainly clinical and can be supported using scales or questionnaires. The diagnostic delay is estimated at around 10 years. This delay is clearly related to the heterogeneity of the clinical expression of the disease. The phenotype of the disease is relative because how patients experience time is relative to the environment they inhabit.

The study of the literature shows that this delay in treatment seriously affects the prognosis, particularly on the functional level, and constitutes a major public health problem. In addition, there are no good biomarkers, easily usable in current practice, to help the clinical decision for the diagnosis or for predicting the course or prognosis of the disease.  One thing is known about bipolar people.  Many of them have the same changes in their eye as diabetics.  They also tend to get metabolic syndrome in the guts more frequently than any other mental illness as is documented in the cites below. They tend to have pale skin in their thoracic and lumbar regions as well.

WHY ARE SLEEP DISORDERS ALWAYS LINKED TO THIS DISEASE?

Sleep disturbances and sleep/wake rhythms are major in BD. These disturbances are observed during the different phases of the disease and are major symptoms of mood episodes and belong to the diagnostic criteria for depression, hypomania, and mania. In addition, these anomalies are also found during the euthymic phases of this disease. Indeed, patients suffering from BD would be more likely to present a more evening chronotype and a more languid and rigid circadian type than healthy subjects as well as a decrease in the efficiency of their sleep, an increase in sleep duration, an increased sleep latency and a prolongation of the duration of awakenings after the onset of sleep. These disturbances in sleep and wake/sleep rhythms are associated, among other things, with more frequent relapses, an alteration in the quality of life, and cognitive disorders.

Additionally, neurocognitive deficits are frequently associated with BD. Most typical deteriorations found are impairment of episodic verbal memory, executive functions, processing speed, and sustained attention. These troubles can be present during mood episodes but also in around 30% of patients during euthymic phases. Cognitive deficits of patients with BD have a direct impact on their psychosocial functioning, on the risk of relapse, on treatment adherence, or even on their ability to insight. Their early detection associated with the identification of prognostic and predictive biomarkers of the response to cognitive and functional remediation tools is essential in order to be able to offer early and appropriate treatment.

Due to its embryological origin, the retina is an integral part of the central nervous system. The retina is a complex neural tissue (above in a BD patient), consisting of several layers of retinal neurons. They have structural and functional properties similar to cerebral neurons.  You've seen this laid out in detail in this series.  In addition, molecules involved in brain neurotransmission such as dopamine, serotonin, glutamate, or GABA, are also involved in retinal neurotransmission. The retina is now considered a relevant candidate for the study of neurotransmission abnormalities in neuropsychiatric pathologies. The function of retinal neurons can be measured using the OCT (below) or the electroretinogram (ERG).

ERG is a simple, fast, inexpensive, and non-invasive process that aims to measure the electrical activity of retinal neurons in response to light stimulation and provides indicators of synaptic transmission. This technique can represent an important electrophysiological measurement in biomarker research within psychiatric diseases. However, studies evaluating retinal function with ERG in BD are very few today.  I think in the future  In addition to the electrophysiological anomalies mentioned above, structural anomalies at the retinal level have been described. Indeed, several studies carried out in optical coherence tomography (OCT) have shown that subjects with BD present a thinning of the layers of retinal neurons. Additionally, results also seem to suggest that retinal thinning in the periphery of the retina where melanopsin is located may be related to disease progression.  People with bipolar disease are exquisitely sensitive to light at night it appears.  This is what makes them different.

As previously described elsewhere on Patreon, retinal neurons and cortical neurons have similar properties. It should be noted that measurements of retinal function with ERG and measurements of cortical function with visual evoked potentials (VEP) share the same characteristics. Indeed, both can be performed using light flash stimulation and using luminous black-and-white reversing checkerboard (pattern stimulation). In addition, they are complementary measures for the analysis of dysfunctions of the central visual pathways. Thus, the combined study of VEP using EEG could be relevant and complementary to ERG for a study of all visual neural pathways in neuropsychiatric pathologies in the future.  I think OCT shows these changes when clinicians think to order them in bipolar patients.  This is going to be how centralized medicine slowly decentralizes in my opinion as these tests reveal the quantum mechanical changes that occur in the antennae of the phased loop signaling you are about to learn about in this blog.

BIPOLAR DISEASES AND LITHIUM & METABOLIC SYNDROME

Lithium is the most common drug used to treat bipolar disorder.  Overall, compared to a placebo, lithium appears to decrease the risk of suicide by more than 60% in bipolar disorder.

Blue light increases blood glucose and insulin from POMC cleavage of ACTH and CLIP.  Did you know that people with newly diagnosed bipolar disorder are 3.5 times more likely to have metabolic syndrome? What is the connection?  Abnormal light in their night environment is the link.  Metabolic syndrome changes how the gut works with the brain because of changes in the SCN and the CSF that surrounds the thalamus.  It is most often seen in those who live an indoor existence while bathing themselves in blue light and nnEMF.  

The best way to avoid all mental illness is to remain in the sun and remain in the dark when the sun sets.   It is not that hard when you understand how light changes the topology of the eye, skin, and gut.  When you bathe in light at night or day mental illness and a sleep disorder will find you eventually in some way.

ISOTOPIC LESSON ON LITHIUM:  DEEP PHYSICS

Lithium drugs are widely used for treating bipolar disorder. They work, but nobody really knows how they work in cells. I think I might. How might a mitochondriac attack this problem? How about by mito-hacking the periodic table of elements yet again?

Consider the link between size discrepancy and the proton spin crisis between B-meson and protons. B-mesons are approximately 2/3 the size of protons and each of the quarks that make them up have a spin of 1/2. Protons do not follow the expected spin predictions that mesons have given us. Why would lithium be linked to this proton story? Remember that mitochondria in neurons deal with protons and B-mesons in the mitochondrial matrix as I laid out in my April 2016 webinar on this topic.  Those details are not important here but the size difference of the atoms is.

Might lithium's effects somehow be due to the quantum effects of the size variation of isotopes found in the matrix in the SCN and the leptin-melanocortin pathways in some areas as it travels through the brain?

You do know that different isotopes of elements have different nuclear spins, right?  People who listened to my Kruse for Dummies lecture should now fully understand why lithium works in bipolar disorder and why it can help reverse some of their Metabolic syndrome effects. Lithium alters the binary code of life because it has a spin number that mimics one of the atoms used in the binary code of biology.

Guess why a mitochondrion favors protium (H+) over deuterium (D)?  Atomic mass is the answer.

Might isotopic effects cause some quantum change in a material or a receiver built into our system? Might the size variation of isotopes found in the blood be linked by Nature to make circulating blood act differently than water in other parts of our body?   LINK TO THE LECTURE

IS BIPOLAR DISEASE REALLY AN ALTERED SIMULATION OF REALITY DUE TO ISOTOPE VARIATION IN NEURONS?

Deuterium is an isotope with spin = 1, unlike hydrogen-1, which has spin = 1/2.

Photons (particles of light) can have a spin of –1 or +1.

Why can't photons have 0 spins?

The definition of the spin as the angular momentum of a particle at rest is also inapplicable to the photon since there is no rest frame for the photon, which moves at the speed of light. Light never rests or stands still once it is liberated from matter.

What bends space/time? Mass does. Since Deuterium has more mass than H+ it bends space/time more than protium. Now ask yourself what magnetic fields do to space-time.  Any guess?  

By reanalyzing the basic equations of general relativity, a researcher has discovered that magnetic fields tend to flatten and stiffen the fabric of space-time when masses are added to them.

How does this affect the wireless magnetic circuits between the sun, earth, and the human brain?

It should immediately raise a question in your mind.  What is it about this solar circuit in bipolar patients, that makes the daytime powerful for them?  Daytime has strong electric fields associated with solar light.  Nighttime has little charge available.

Does a strong electric field cause time dilation in the SCN and the tracts linked to it in the mammalian brain?  What does that light do to water filled with deuterium in the bipolar brain? 

It appears you need a ton of sunlight to offset this effect.  What if you live at a high latitude?  Will that help this disease?  Nope.  Why?  Physics holds the answer.

The spacetime curvature for a charged static spherical body is given by the Reissner–Nordström metric:

With these mathematics, you can feed in the value of whatever charge you want and calculate the time dilation as a function of distance from the charged body. If you do this you'll discover something rather odd in Einstein's field equations, namely, the charge reverses the effect of the mass in them.

How do cells increase their charge?  

LIGHT DOES IT

Do you remember how many times I have told you in podcasts that redox potential is formed by adding net negative charges in a cell?  Do you see now how that charge can offset the bad isotopic variation in some of your tissues to make your clocks work better in the circuit that tells the brain what season it is?  This is another universal law not subject to an RCT.  

Remember sunlight deuterium depletes our tissues in many ways.  Light at night adds massive, via deuterium to our tissues and the water networks in our brain. This is how mass is added to human tissues.  The more mass added means the more sunlight you need to raise the charge to offset your light addiction at night.  How do you do this?  Your cells need to create light so you can create melanin & water from POMC and mitochondria respectively, to add charge to your tissues.  This energy then can be absorbed and stored at the vibrational levels in cells for later use.  Without that charge, our SCN & molecular clock function is degraded.  Degrade clocks = poor periodicity.  All of these are OLD LESSONS FROM OLD BLOGS FOR YOU NOW.

Is this why mammals conserve charge using their POMC biology in their cells Uncle Jack to offset this deuterium problem?  Yep.  The excess mass of heavier isotopes in cells and mitochondria causes time to slow (relative to the observer at infinity) but adding charges back to proteins/water (of either sign) can make the time speed up again.

Wait a minute Dr. Kruse, explain that again like I am a 3rd grader.

The sun creates massive electric fields during daylight. Implications for Bipolar Disorder?

Does a strong electric field cause time dilation in the universe?  Yes, it does because a strong electric field generated by the sun adds a massive net negative charge to cells that absorb this radiation.  POMC makes sure this happens in the human brain via Noether's theorem.

This is true because the mathematics of physics says it operates this way.

It appears this is what really causes Bipolar disorder at its fundamental core.

TYING IT BACK TO MY THESIS OF THIS SERIES: POMC

The adrenal medulla of mammals was born under the light stress of the KT event. This is why I wrote the adrenal fatigue blog years ago but no one saw things back then like they do now. I told the implications of that Huberman/Rubin podcast were VAST.  Bipolar disorder is one of these VAST effects.

Man's five senses can capture the vastness and the immensity of our cosmos and POMC is the paintbrush that allows it. POMC is the paint that goes on the canvas, your brain. POMC is a color palate that humans use to paint their minds. In some ways, that palate confines us to the limited real estate of the sensory organs in our brains to understand all the complexity of the universe. All 5 senses tract directly to the thalamus of humans which surrounds the 3rd ventricle of their brains.  But there is wisdom in being connected to nature in this fashion. Yet, few see the artistic symmetry of confinement. I am trying to explain this art to you now every day, in every word I write in every one of these blogs.  It is time for you to LEVER UP your knowledge.

THE LEVER-UP LESSON:  The adrenal cortex synthesizes three main groups of hormones (glucocorticoids, mineralocorticoids, and adrenal androgens) (Auchus and Miller, 2001). The homeostasis of glucocorticoids is regulated by a feedback mechanism CONTROLLED BY POMC gene translation via solar light and temperature sensors (non-visual photoreceptors) in the skin, eye, and autonomic nervous systems that are relayed to and through the hypothalamic POMC centers in many neuron tracts and in the circumventricular organs (water networks in the ventricular system of the brain) by means of corticotropin-releasing hormone (CRH), the pituitary gland by ACTH, and the adrenal cortex by cortisol (Koch, 2004).

The mammalian cell responds to all stress, including light stress, by increasing cholesterol production.

Cholesterol is the MAIN non-visual photoreceptor of the brain.  If you go into an ICU with a patient with an acute infection and draw their lipids (not often done except by a tool like me) you will find sky-high LDL cholesterol.

And that is both LDL and HDL, but the LDL fraction is much higher. Is that a problem? No. But Big Pharma has trained centralized MDs to reflexively reach for the Rx pad to write for a statin. This is why so many people with Bipolar disorder also have metabolic syndrome as a comorbidity as well.  Their LDL is high because they are all solar deficient.  Remember LDL cholesterol lacks electrons relative to HDL cholesterol.

The other non-visual photoreceptor in the brain that is common is melanopsin and it is found in the blood vessels.  Blue light at night, increases cerebral blood flow and increases blood pressure excessively.  High blood pressure is part of metabolic syndrome.

Few MDs & psychiatrists today are trained to even know full spectrum sunlight lowers cholesterol naturally.  Even fewer realize sunlight is the best treatment option for Bipolar disorder.  Most of them have no clue that the light where most humans have bipolar disorder is not strong enough to get rid of deuterium.  Blue light at night is an additive effect that makes this disease deadly.

This is why there are several formats of this disease as you saw in the video above. That mimics heteroplasmy in the system.

In fact, in metabolic syndrome, higher LDL cholesterol stabilizes the inner mitochondrial membrane function during heavy oxidative phosphorylation (cellular energy production). So a raised LDL actually helps mitochondria retain its electric charge to condense H+ inside the mitochondrial matrix to make energy using the light hydrogen isotope.

This is how the cell controls space time and magnetic fields inside of their tissues to ACCURATELY SIMULATE THE PHYSICS OF YOUR ENVIRONMENT.

^^^^That idea was in the recent Time Crystal blog.  Did you read it?  

In bipolar disorder, this is a broken mechanism at the level of the SCN because there are atoms in it with higher masses than there should be.  (D > H+)

Do you know what sits really close to the outer mitochondrial membrane in most mammalian cells?

POMC waiting to create melanin from the biophotons released from the mitochondria right next to it. Making CO2 and DDW is the reason our cells stole bacteria 600 million years ago. And since the cell is trying to recover from a light stressor, it needs a good inner mitochondrial membrane in which to transfer its electrons to oxygen and use the H+ liberated by melanin buried in water to make ATP by the spinning ATPase Fo head.

When the deuterium isotopic variation mechanism is broken in the SCN, lithium can be used to help offset that loss in the CSF networks in the ventricular system of the brain.  Effectively, lithium is adding mass to the water of CSF to offset the deuterium in the SCN to allow it to act as a better FM radio antenna to tell the season for the brain.

That is why lithium can help some of these people.

Lithium creates huge electric currents in cells.  This is why cells do not use it under our solar spectrum.  The problem with lithium is that it can never reverse the disease and you'll get that when you understand the physics of this disease.  

Only strict sun tropical exposure during the day and EXTREME darkness at night can repair the broken mechanism at the SCN level to help eradicate this disease in humans.  When the SCN is loaded with too much deuterium, as such, it cannot accurately tell time at all.  It will do best on June 21st.  In people with BD on lithium this is when the strong sun can set them off because that light can overpower their system because lithium creates massive uncontrolled electric surges in tissues because of its atomic size and spin.  

The isotopic variation of hydrogen changes in their tissues as their choices in light vary leading to mania and depression cycles in things the ipRGCs link directly to.  Note the positioning of the habenular nucleus in the next two pictures and you'll see the circuit manifest before your eyes.

What controls the autonomic nervous system in the gut of mammals that get metabolic syndrome?

NEUROANATOMY LESSON TIME:  POMC does because it is found in high concentration normally in the outflow tracts of the neurons from the hypothalamus that connect the hypothalamus to the gut.  This connection is made via the dorsal longitudinal fasciculus.  That is a tract I have not taught you too much about.  

That tract targets the thoracic nerves that connect to somites where other melanin stores are located from the neural crest. (key point) 

Remember before when I told you bipolar people tend to have pale trunks and abdominal skin?  Where do humans have the most POMC in their skin?  Thoracic and abdominal skin.  Now you know why this link is important.  These dermatomal layers need melanin renovation CONSTANTLY in BD to get rid of deuterium.  Where is the deuterium below?  It is in the enlarged ventricles and in the white matter tracts that have all these white spots in them below.  

When I see a patient with BD I always examine their skin in these areas before I order an MRI (above).  Why?  

Pale skin in these areas always correlates to white matter lesions in the brain (shown above).  Centralized science is still clueless why this is the case.  You no longer will be.  This is decentralized medicine 101.  

White matter hyperintensities (WMH) are much more common in subjects with bipolar disorder (BP) than in healthy subjects.  The more prominent that lesion or the larger their ventricles tell me how severe their disease is.  LINK   I have also observed that the paleness of the skin in these areas also correlates with the thickening of the choroid on OCT images of the retina and with changes in the inferior nasal retina on my eye exams.  today I saw three patients with altered ventricular anatomy in the ER.  I expected it.  The ED doctors did not.  

The hypothalamus is the key brain site for central control of the autonomic nervous system, and the paraventricular nucleus is the key hypothalamic site for this control. 

Much of the medial surface of the thalamus and hypothalamus form the wall of the third ventricle pictured above. Part of the hypothalamus forms its floor. 

Its thin, membranous roof contains the choroid plexus that makes cerebrospinal fluid which is 99.8% water. The third ventricle narrows quickly at the posterior end of the mammillary bodies.  These mammillary bodies are the key to memory formation and are important in dreaming during sleep.  When you do not dream and cannot remember it I know exactly where your POMC defect is. I know what to look for on MRI. 

Anatomically, the PVN is adjacent to the third ventricle, and many of its neurons project to the posterior pituitary. These projecting neurons secrete oxytocin and a smaller amount of vasopressin, otherwise, the nucleus also secretes corticotropin-releasing hormone (CRH) and thyrotropin-releasing hormone (TRH).

Recall my Brain-Gut #16 blog told you that the PVN is where adrenal fatigue began.  It is a light disease that turns off POMC in the hypothalamus and is not a real adrenal disease.

The PVM neurons massively express POMC but without UV light this switch never gets turned on. Bipolar patients are all lacking that critical UV light switch.  That means this pathway is turned off or is suffering a brownout.  You do not have a vagal problem, you have an autonomic nervous system slow down due to a lack of charge density there.

The major pathway from the hypothalamus for autonomic control is the dorsal longitudinal fasciculus in the human brain.  Below is another picture of the third ventricle (red box) that is adjacent to the hypothalamus and thalamus in humans.

The dorsal longitudinal fasciculus (fasciculus of Schutz) is a periaqueductal (area around ventricular system Aq above) ascending and descending fiber system arising from the hypothalamus and terminating to the autonomic nuclei of the pons and the medulla, conveying autonomic fibers from the brain to the gut in humans.  It also conveys pain messages and is important in the sleep pathways of humans.  These are usually altered in bipolar patients as well because of a lack of melanin in these areas.

The dorsal longitudinal fasciculus is found within the dorsal brainstem tegmentum. It passes through the periaqueductal gray matter and contains both ascending and descending fibers. The ascending fibers pass from the reticular formation (sleep region/insomnia) passing to the hypothalamus thus transmitting information related to the viscera in the thorax and abdomen.

People who travel a lot across time zones or people who use a lot of blue light or nnEMF at night or day in their cities are going to have massive sleep disturbances because they lack charge density in this spot.  They mimic people with mental disorders like bipolar patients because they have broken the same rules of Nature.  I view insomnia as a mental disorder in my decentralized medicine framework.

This topologic neuronal surface is a critical barrier to the brain health of humans.  This is the pathway where metabolic syndrome, poor sleep, and fatty liver all come from fundamentally.  This pathway could be in many blogs but I left it out this detail.  Why?  You already thought this stuff was too hard.  Why add another level of complexity with neuroanatomy?    

Many of these same findings are found in diabetics, bipolar disorder, and those with sleep disorders like insomnia.  Patients with bipolar disorder tend to have all these symptoms at times that vary based on how defective their FM antennae are in their eyes & brains.  

This explains how a lack of sunlight leads to most gut and sleep issues modern humans face. Without proper DLF input to the gut via the brainstem, ferroelectric currents are lost and circadian control of the gut lumen is awry. None of their molecular clocks work there as a result.  This opens the gut barrier to many potential problems.  Every patient I have seen with a gut issue has this common mechanism.

Pro-opiomelanocortin co-localizes with corticotropin-releasing factor in axon terminals of the noradrenergic nucleus locus ceruleus.  It is not just a PVN story folks. Where the problems lie will determine aspects of the disease you get.
This nucleus is filled with neuromelanin. 

Why do bipolar patients struggle with drugs and pain meds 7 the placebo effect? 

The locus ceruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread brain regions, especially the hypothalamus, and projects throughout the forebrain, brainstem, cerebellum, and spinal cord.

What is the main function of locus ceruleus?

It is the brain's main source of the neurotransmitter noradrenaline (norepinephrine). This chemical is excitatory and is released in response to pain or stress, stimulating what is referred to as the 'fight-or-flight' mechanism. This means that it activates the sympathetic nervous system via those thoracic nerves I mentioned above.  

Those are the same nerves that innervate your brown fat and also give input to the superior cervical ganglia that I mentioned in Time 12 blog long ago.  Without UV light exposure in the eye and skin in these dermatomes melanin is degraded and noradrenaline is diminished.  You remember that noradrenalin can be made from melanin right?  You need highly oxygenated environments to keep noradrenalin stored and when the flight or fight response comes the hypoxic effect changes how the system operates.  NA can be degraded to L-DOPA to make other chemicals needed in many places of the brain. See the slide below the far right top line.

Neuropsin is a 380 nm light sensor that the locus ceruleus needs to function well.

Without this non-visual photoreceptor system operational, this opens the BBB and the gut barriers. Now you see why Nature put neuropsin in your eye and skin.  We see this in most psychiatric cases and in TBI cases due to the light stress response.  Now you can see why really the brain-gut barrier is linked. Usually, there is a lack of melanin in the DLF and/or the locus ceruleus to create the aura of brain-gut barrier when in reality what links the two is a lack of UV light to stimulate POMC in both hypothalamic pathways and melanin is degraded leading to many disease phenotypes.  

Each somite in the spinal cord also has POMC genes in them ready to be activated.  They are derived from the neural crest in this part of the body.  For the gut, this is linked to the celiac ganglion which comes from T5 -T11 thoracic nerves.  So thoracic level solar exposure is key to renovating gut-level melanin.  It is counterintuitive until you see it all laid out in front of you.  A lot of this deep science would have been in the Vermont 2019 video I was going to give 4 years ago.  I think I still might do it for the Kruse for Dummies folks as their next lesson.

SUMMARY

Neil Cherry Ph.D. from New Zealand showed in 2002 that there is strong and robust scientific evidence of the human brain detects and responds to the Schumann Resonance signal based on the work of many researchers Robert O. Becker worked with in the 1970s.  People with bipolar disorder cannot connect well with the Schumann resonance because of excess mass contained within the receivers of the signal which comes from the sun and Earth.  As a result, this leads to behavioral and neurologic dysfunction.  Since the increased mass of isotopes used in this system affects coherence times that are possible in cells, they lose their ability to maintain quantum coherence and the system becomes dysfunctional.  How long a system can maintain coherence is a function of the atomic mass in that system.  You can see now why any additional masses in the SCN or habenular nucleus destroy this relationship.  The pictures below show the specific details of the pathology laid out for you.

The brain uses a range of frequency patterns monitored by the EEG system in our neurosurgical clinics. The frequency range of the EEG rhythms coincides with the frequency range of the Schumann Resonance signal (0–45Hz). The alpha wave is identical to the frequency most commonly linked with Schumann's resonance on Earth.  The normal brain has developed an ELF oscillating ion system, primarily using calcium ions (above), to control neurotransmitter release.  The release is awry in BD.  Dr. Russ Adey at UCLA established this in the 1970s.  Adey's work is cited below. The human brain and its optical clock lattice in the SCN are now well-established in the literature.  

Blackman's work on calcium ion resonance frequencies was cited multiple times in Becker's books and my early blogs on the non-ionizing effects of nnEMF and neurological compromise. Blackman's research also cited below, has taught decentralized MDs that external electromagnetic ELF signals induce altered neuron calcium ion effluxes in mitochondria of brain tissue.

These ELF signals between the sun and Earth are weak, yet they match the ultraweak UV biophotons that cells create in response to the Schumann extraterrestrial signal.  This allows the brain to know the season.  The stable synchronization of the brain's electromagnetic systems using a system that mimics an FM radio has actually led to humans becoming thinking, emotional, and memory machines of biology that are capable of quite a bit of intelligence in the human central nervous system. In order to carry out these functions the brain has developed electromagnetic transmitters and receivers in the neurons to accomplish this task in the SCN, leptin melanocortin pathway that extends into the thalamus of man and into his spinal cord.  The thalamus is where the alpha wave finds its genesis in humans. This connection is pictured below.

The receivers used by Mother Nature mimic an FM radio in your car.  Yes, the human brain has a built-in FM radio system.  I was not joking above.  In the human brain, there is included a phase-locked loop system, described by Ahissar et al.  This paper is cited below. 

A phase-locked loop system = modern FM radio receivers in your car.  

In the human brain, the FM radio receiver interacts with the Schumann Resonance signal.  The phase-locked loop is a very useful circuit block that is widely used in radio frequency or wireless applications in tech gear.  Given its usefulness, the phase-locked loop or PLL is found in many wireless, radio, and general electronic items from mobile phones to broadcast radios, televisions to Wi-Fi routers, walkie-talkie radios to professional communications systems, and much more.

Mother Nature built this system over 3 billion years ago in the brains of living systems to inform cells of the seasonal connection between the sun and Earth so this data could be useful for seasonal biological changes in living things.  In bipolar disorder, this system is awry when it is encumbered by too much mass in the receivers of the FM radio.

The circadian activity generated in the SCN needs to be transmitted to the rest of the brain and henceforth to the rest of the body via non-optical signaling to stay well. In Bipolar Disorder this is impossible because the SCN is where the main deuterium defect lies.  

That EMF receiver is not receptive to Schumann's information.  Coherent connection ruins the fidelity of the system.  Most of the centralized science right now believes it is through direct wiring tracts. I do not. I think it happens via the hydrogen bonding network in the circumventricular organs filled with CSF water.  These areas in your brain have no blood-brain barrier by design.  

This provides the fidelity of the phased locked loop design. This allows electron and proton tunneling and quantum coherence to allow for rapid communication in the system. I believe all biological processes in any living organism are due to the creation of biological biophotons in the ultraweak VUV-IR-A range. Light can dictate highly selective and specific electromagnetic interactions between particular biomolecules because of changes in mass or the magnetic moments of the component boxcars of biochemistry. In most cases, these interactions involve and are driven by semiconductive proteins surrounded by water, which act as logic gates do in the system of organization seen in solid-state physics.

The human brain SCN contains the key mechanism to having a strong diurnal pattern that assists the sun to maintain the circadian rhythm.   The Schumann Resonance signal continuously synchronizes the brain wave ELF patterns in a set range of grouped frequencies that begin in the thalamus that surrounds the 3rd ventricle of the brain.  The ventricular system also acts as a resonant cavity on Earth to receive these signals.  

The hydrogen bonding network in CSF is another FM-like receiver in the phased locked loop communication system mentioned above.  This stabilizes the brain's electromagnetic system of communication and its fidelity has enabled the evolution of intelligence and consciousness with an ability to provide stable thinking to make predictions.  This system has evolved to the point in humans where this complex understanding of the biophysical environment interacting with the human brain can be reasoned, understood, and appreciated.

DNA only codes for the key backbone proteins that will become the main conductors of any life process within the organism. The mitochondrial matrix created the other part (water hydrogen bonding network) of this semiconductive backbone in cells to surround the protein.  Both parts of the semiconductor have to be operational to simulate time from your environment at the level of the SCN.  Everyone focuses on refraction errors in the eyes.  Few spend time understanding how the eye clock really operates at a quantum mechanical level with the Schumann frequency.  This is why psychiatry remains impotent to help reverse this disease.

Let's review the lessons from 100's my blogs now in relation to this disease.

A. Hydrogen bonds form between water molecules, giving rise to supramolecular aggregates/clusters/coherent domains. Some call this EZ water.  The clustering of water is a cooperative phenomenon, which means that forming one hydrogen immediately favors the formation of several other hydrogen bonds, and vice versa, breaking one bond leads to breaking up a whole cluster. Thus clusters are dynamic flickering networks with lifetimes of 10^- 11 to 10^-10 seconds. Light changes those hydrogen bonding networks by moving charges around.
https://phys.org/news/2022-10-revolutionary-technique-hydrogen-efficiently.html

B. Hydrogen bonds are the key to coherence in cells. Hydrogen bonds act like a spec of dust in the formation of snow, ice, or crystals.

How do coherent excitations make the system sensitive to specific, weak signals? Such a weak signal will be received by the system only when the system is ‘in tune’ — rather like a very sensitive FM radio receiver, which can resonate to the signal. Furthermore, a small signal will be greatly amplified for it will not only affect one molecule, but because many other molecules are in the same state of readiness, they too, will be affected in the same way, and the signal is correspondingly multiplied as many times as there are molecules responding to it.

The shape of your ventricular system which is filled with H+/D is another clue for me that the receiver system is broken.

The hydrogen bonds in water have a critical point at which they change and act like dust. When enough energy is pumped in bond angles change and this makes water liquid crystalline and a better antenna to receive signals of what season it really is.  People with bipolar disorder have bad FM antennas.

More lessons from old blogs you need to recall now to understand Bipolar:

C. Sunlight creates electric fields in our atmosphere every day and that sunlight creates a Coulomb force in our body. Coulomb force is an electrostatic force. Electrostatic phenomena arise from the forces that electric charges exert on each other. Coulomb's law describes such forces. Even though electrostatically induced forces seem to be rather weak because of how we experience them in life, when the scale shrinks, as it does in a cell, the electrostatic force increases tremendously in strength as the scale drops. Scale drops = less mass present

D. For example, some electrostatic forces such as the one between an electron and a proton, that together make up a hydrogen atom, are about 36 orders of magnitude stronger than the gravitational force acting between them. The electrostatic force generated in your skin is another example of a strong electrostatic force because the skin, as an insulator can hold large amounts of charge from the sun if it is normal.  It is not in bipolar disorder.

E. Modern physics now has proven that energy and information are equivalent in physics. Landauer's Principle of 1961 & Shannon's 1948 work was critical in making this linkage. Modern quantum biology has experimentally proven that energy is trapped directly at the electronic level in cells. Energy is stored not only as vibrational and electronic bond energies in biochemicals, but also in the structure of the system: its membranes, and in gradients, fields and flow patterns, compartments, organelles, cell water, and tissues. All this in turn enables organisms to mobilize their energies coherently at any time it is needed and hence make available the entire spectrum of stored energies for physiological work. It is energy on demand by atomic design.

F. What is the bandwidth of the entire electromagnetic spectrum of light? The electromagnetic spectrum starts from wavelengths of 10^-14 m at one extreme to 10^8 m at the other, spanning a range of 10^22. In terms of doublings, 10^22 ≈ 273, or 73 octaves. Visible light is a small fraction of this bandwidth but that bandwidth does very specific things that cells take full advantage of.


Light is an EMF. Sunlight (visible light) is a very specific EMF that interacts with specificity for atoms in cells. That specificity is created because the EMF selects the type of water created by the dissipative system. This DDW water surrounds the atomic lattice inside cells whose integrity is maintained by the nuclear genome blueprint. The atomic arrangement in cells also allows for light absorption and light emission. The light that cells emit is also quite specific. It is an ultraweak extreme low-frequency biophoton that spans the visible spectrum frequencies. This is the light that is used for optical signaling and it drives the molecular resonances that drive the internal motions of biochemicals in cells. Light drives biochemistry. Biochemistry does not drive light.  

Conventional centralized biochemists do not understand these nuances of what biophotons are and how they are created by EMFs, water, and oxygen in cells. So You should not expect centralized physicians (psychiatrists) to get this nuance either.

G. Claude Shannon taught the world that information flows via entropy. All clocks should be thought of as flowmeters for entry. This includes the biological circadian clocks in cells. Wheeler taught physics that information and energy are one and the same thing. Shannon’s mathematics from his 1948 paper advanced the linkage of entropy and information. Shannon's paper also told us anything can be a message.  (Kruse for Dummies lecture)  H+ and electrons are fermions.  Deuterium is a boson and this small difference can ruin how an FM antenna works.

I believe sunlight messages for mitochondrial DNA and nuclear are controlled by "fermion messaging" (pic above from old blogs). DNA is informed about what to do with optical information from the sun via mtDNA signaling (optical and free radical) and this message is transmitted over water's hydrogen bonds adjacent to proteins in a cell. DNA is a very complex topologic insulator that is an antenna for our star's information.

H. Water makes up 99% of molecules in every cell and it fills the ventricles of our brain. Water is a very small molecule that has more hydrogen bonds in it than any other compound. Liquid water contains the densest hydrogen bonding of any solvent, with almost as many hydrogen bonds as there are covalent bonds and hydrogen bonds in its structure found anywhere on Earth. These two bonding networks are the binary code in water. Just as a computer can use a 1 and 0 to create digital information on the internet, hydrogen bonds create the internet in your cells. Shannon taught us the information content of any kind of message could be measured in binary digits or just bits. This was the basis of the Kruse for Dummies talk.

I. Water's hydrogen bond network changes at a pico and femtosecond level in any environment. Inside a cell, its atomic arrangement is controlled by electrostatic forces in a cell created by the redox power of the mitochondria in that cell. These hydrogen bonds can rapidly rearrange in response to, light frequencies, charge density, and changing conditions and environments (for example, solutes like K+ in a cell).  This is how our ventricles tell seasons in us.  

It is also how neurosurgeons should use MRIs differently to diagnose clock disorders in their patients.  I know I do it every day.  Normal pressure hydrocephalus for me is diagnostic of a brain filled with deuterium and a completely disordered clock system.  These people are walking time bombs for intracranial clots and neurodegeneration.  POMC is degraded massively in these patients.  

When the FM system is bad in the neocortex, brainstem, and  thoracic spinal thalamic tract you cannot tell seasons and bipolar disorder is the result. 

J. Shannon demonstrated, contrary to what was commonly believed in the 1940s, that engineers could beat their worst enemy ever: transmission errors-or in their technical jargon, "noise." Noise is anything that disturbs communication. Your FM radio antenna does not work when there is noise in the system.  It can be an electric signal in a telephone wire that causes crosstalk in an adjacent wire, a thunderstorm static that perturbs TV signals distorting the image on the screen, or a failure in network noise to increase the energy of the transmission signals or send the same message repeatedly-much as when, in a crowded pub, you have to shout for a beer several times. Shannon showed a better way to avoid errors without wasting so much energy and time: coding. 

Nature does the same thing.

She takes the message in the hydrogen bonding network of water that surrounds every protein and encodes that information in fermionic code in mRNA, mtDNA, RNA, tRNA, and DNA. Deuterium is a BOSON.  It ruins the fermionic signal and that CAUSES bipolar disorder.

DO YOU GET IT YET?  

K. Coding is at the heart of information theory. All communication processes need some sort of coding to limit the noise and create a high-fidelity signal that doesn't degrade. Bipolar disorder is due to tissues in our FM radio station in our heads having too much mass in them.  Water preserves the information and transfers it to nucleic acids via hydrogen bonds. Just as the telephone system transforms the spoken voice into electrical signals. In Morse code, letters are transmitted with combinations of dots and dashes. The DNA molecule specifies a protein's structure with four types of genetic bases. Digital communication systems use bits to represent or encoded information. Each letter of the alphabet, for example, can be represented with a group of bits, a sequence of zeroes, and ones. You can assign any number of bits to each letter and arrange the bits in any way you want. In other words, you can create as many codes as desired. Cells have done this to run life's program.  

The more mass a tissue has the less time it can remain quantum coherent to transfer information in any system.

All of these lettered lessons above ^^^^^ have been published in my blogs or forum for years.  Please ASSIMILATE THEM NOW.

If you do not believe me review this thread:  https://forum.jackkruse.com/threads/mitochondrial-thermodynamics-diy-lesson-thread.27408/

This blog was easy to write because pieces and parts of it are in hundreds of other blogs.

The emission and absorption spectra of proteins can be used to make predictions of what light frequencies will couple with proteins and the matrix to create DDW water. The logic in the system of operation can only be comprehended when you understand how the subatomic parts of nature are able to be used and manipulated by quantum mechanical abilities. I told you a long time ago, in the Cold Thermogenesis series, that the default state of life was sleep.  Then as evolution progressed with evolved wakefulness.  This idea was counterintuitive to many at the time.  The reason for my prediction was simple.  I read Feynman's 1982 paper on a computer simulating the physics of the environment and thought to myself what organ in humans fit his description of an ability to simulate the physics of Nature?  The SCN fit perfectly.

The SCN filled with deuterium and your CSF overwhelmed by deuterium is where bipolar disease comes from.  Patients with Bipolar Disorder also have a higher risk associated with retinal detachment, primary retinopathy, diabetes retinopathy, big ugly ventricles, hypertensive retinopathy, and retinal vascular complications than the controls.  Now you all know why this blog came after the last one.  The symptoms begin in the eye and retina.  

Please re-read QE # 44-47 again.  The concepts are there to explain this disease and all sleep disorders.  The last blog was on diabetic retinopathy.  Those patients also always have features of metabolic syndrome.  So do most mental disorders and sleep disorders.  Now you can see why they are all linked.  You have effectively broken the FM antenna station nature put inside your skull.  If you have insomnia, (yes, Sam this was for you before I banned you)  part of your system in the periaqueductal grey area is broken in your brain because you loaded this area up with deuterium by using Netflix too often while traveling outside your time zone too much for your brain, and you decided to live in Chicago with all its associated nnEMF and population density.  It should be obvious why you cannot sleep under these circumstances, no?

What I am explaining to you now is where in the topological map of the human brain the POMC deficit is located leads to the phenotype of the disease we see in our clinics.  Patients with this disorder intuitively know they need more sun.  How they go about it is often incorrect as you see in cite 4 below.

Understanding the human eye and retina and linking it to entropy in a cell was the only quantum leap I made to understand this concept.  The flow of entropy is why I made this prediction back in 2010.  All molecular clocks are flow meters for entropy.  I knew the SCN had to be doing something unusual with the retina and the brain during sleep.  The SCN appears to be a perpetual motion machine built into the brain.  Feynman wrote a paper in 1982 stating he believed a quantum computer could simulate physics if it used a time crystal.

The SCN is a small computer in your eye that is simulating the physics of the environment between the sun and Earth to make the best predictions for cells in tissues.  In bipolar disease that time crystal is not working well because the mass inside of it put there by the light you allow ruins it.  Adding mass back to the water networks, using lithium is how lithium operates.

The problem is the system fidelity operates at quantum mechanical precision with respect to mass and this is why results are so uneven in patients with this disease.

GAME, SET, MATCH

CITES

https://www.psychiatryadvisor.com/home/topics/mood-disorders/bipolar-disorder/increased-metabolic-syndrome-prevalence-rates-linked-to-newly-diagnosed-bipolar-disorder/

https://www.patreon.com/posts/quantum-44-your-83629619

https://pubmed.ncbi.nlm.nih.gov/34994991/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860187/

Adey W. R. Electromagnetic fields and the essence of living systems. In: J. Bach Anderson (ed). Modern Radio Science. Oxford University Press; 1990. p. 1–37.

Ahissar, E., Haidarliu, S., Zacksenhouse, M., 1997. Decoding temporally encoded sensory input by cortical oscillations and thalamic phase comparators. Proc. Nat. Acad. Sci. USA 94, 11633–11638.

Blackman C. F. ELF effects on calcium homeostasis. In: B. W. Wilson, R. G. Stevens, L. E. Anderson (eds). Extremely low-frequency electromagnetic fields: The question of cancer. Columbus: Publ. Battelle Press, 1990: 187–208.

Cherry N. J. Schumann Resonances, a plausible biophysical mechanism for the human health effects of Solar/ Geomagnetic Activity. Nat Hazards 2002; 26: 279–331.