HYPOXIA #29: T- CELL IMMUNITY, THE SUN, & C19

Sunlight is a gift that brings immunity to many pathogens.  It just so happens the one everyone is interested in now, C-19 is one of those pathogens who has a strict seasonal variability.  

A recent study has shown that Intrinsic Photosensitivity Enhances Motility of T Lymphocytes to improve motility to improve immune protection from pathogens.

Until recently, photoreception in mammals was believed to be restricted to the eye. Since 2017 we now know it is also a property of the skin.

The largest amount of T cells are found in the skin followed by the gut lining.

Normal skin contains a high density of T lymphocytes performing immune surveillance, and the total number of T cells resident in skin is estimated to be double of that in circulation

In this study it is shown that T cells possess intrinsic sensitivity to blue and UV light. Blue light links to T cell hypoxia and UV light decreases hypoxia by increasing oxygen to these cells to create a large free radical pulse to destroy pathogens.

1. Blue light increases [Ca^2+] in T cells which diminishes your immunity = increased C19 risk

Blue-light irradiation of Jurkat T cells triggers an increase in intracellular [Ca^2+] as measured by Fluo4 fluorescence which was followed by extension of lamellipodia

2. Irradiance and spectral dependence of T-cell photosignaling

Data shows that the light response depends on the total number of photons rather than irradiance flux or time and this observation supports the existence of a photon-counting mechanism.

3. Light generates Ca^2+ signals via a Src kinase/PLC-γ1 pathway

Blue-light dose-dependently stimulated phosphorylation of Lck, the dominant Src kinase in Jurkat cells.

4. Light generates H2O2 in T cells to fight viruses*

Flavins are readily photoreduced leading to the generation of ROS including H2O2. Accordingly, they confirmed that blue light irradiation of flavin-containing solutions, at similar doses (600 mJ cm^−2) used on T cells, produced H2O2 in vitro.

To directly and selectively monitor H2O2 levels they transfected Jurkat cells with the genetically-encoded H2O2 reporter, HyPerRed29. The researchers found that a low dose of blue light (300 mJ cm−2, 30 mW) was sufficient to trigger H2O2 production in Jurkat cells.

5. Therefore, we can now say definitively that the light in your environment can enhances T-cell motility* if it is solar based.  We can also say that is decreases T cell function if the light you live under is man made.

The researchers observed that blue-light irradiation altered the morphology of T cells, inducing the extension of lamellipodia. Since motile lamellipodia are associated with cell migration they measured effects of light on T-cell motility by tracking the movement of activated CD8+ T cells across a fibronectin-coated surface. Low levels of blue light (120 mJ cm^−2) increased random T-cell motility and the peak surface area (reflecting spreading lamellipodia), an effect that persisted following irradiation. Thus, T cells exhibit photokinetic behavior.

Next, they measured effects of light on chemotaxis. Figure 5d shows that irradiation with white light (1–5 J cm^−2) enhanced migration of Jurkat T cells towards the T-cell chemokine, stromal-derived factor. Light increased chemotaxis in a dose-dependent manner with a peak 100% increase observed at irradiances greater than 2 J cm^−2.

REMEMBER: There is not a politician on this planet that is going to save you.  Wearing a mask for a nanoscopic virus is pseudoscientific as the recent Danish study showed.  The LA Times seems to have a reading comprehension problem.

This shows you the main stream media is another step closer to George Orwell's Ministry of Truth ("1984"):

The LA Times tweet above was referring to the Danish mask RCT, 𝘄𝗵𝗶𝗰𝗵 𝘀𝗵𝗼𝘄𝗲𝗱 𝘁𝗵𝗮𝘁 𝗺𝗮𝘀𝗸𝘀 𝗮𝗿𝗲 𝗻𝗼𝘁 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲, blatantly lies and reports the exact opposite conclusion!

A new low is made every day to get control of your behavior and life. 

Lock downs are also pseudoscientific.  Politicians could care less about biology; their only interest is in how much control you're willing to give them by decree.

Don't be fooled — you are responsible for yourself. This is a Black Swan mitochondriac axiom. Politicians need to live this axiom: Integrity is not a 90% thing, not a 95% thing; either you have it or you don’t.

#medicine #sunlight #aheadofthecurve #electromagnetic

CITES:

https://lnkd.in/g-vVDyB