HYPOXIA #16: SUNGLASSES = CELLULAR HYPOXIA?

Retinal blood flow increases 40 to 70% after the transition from dark to light in the AM.  This increases blood flow which increases oxygen delivery to the deep retinal structures.  This reduces pseudohypoxia, raises NAD+, while improving the pulse creation of nitric oxide in the retina to improve the microcirculation.  Solar exposure of the retinal actually increases blood flow in the retina so that the entire blood volume in the circulatory system in 15-30 minutes.  This is why AM sunlight exposure is huge for wellness creation.

This also points out why wearing contacts, glasses, and sunglasses can be lead to disease and and an early death.  For those who think this is hyperbole, look at the page from John Ott's book called Health and Light, and read for yourself what Albert Schweitzer found in Africa when natives were given sunglasses.  Cancers began to manifest.  Instead of disbelieving this observation from 100 years ago, spend some time reading the new science recently published that show the precise mechanism of how this happens.  It is included in this blog. 

Emerging research is illuminating the dark side of wearing sunshades that links to hypoxia and photoreceptor damage. Sunglasses alter the solar frequencies to trick the brain by changing the solar frequency spectrum the eye senses into thinking it’s dark and prevent it from producing a hormone (melanin) using nitric oxide pulses that protects against sunburn, according to new research.

Tryptophan is an aromatic amino acid which make melatonin.  Tryptophan has to be programmed with UV/IR-A light to work properly in cells as I covered in the QT-14 blog on patreon and this picture below.

Tryptophan creates serotonin and melatonin and they are other key light mediated hormones.  serotonin affects behavior and mental abilities and melatonin controls energy production from mitochondria.  The melatonin hormone curbs the creation of the cancer state in cells when it is created in cells by UV and IR-A light from the sun.  This makes sunlight nature's vaccine for cancer.  Anything that destroys melatonin levels makes cancer much more likely possibility.  This is why poor sleep links to many bad diseases. 

So why in God's green Earth would anyone believe that suncreen or sunglasses are helpful to health when you know this PEER reviewed science since both lower our ability to make melatonin?  

PROFIT is the only logical answer.  

What is the science behind this claim?  Take a look at this paper via the HYPERLINK 

When we have an inhibition of the pineal function with pinealectomy or via the chronic exposure of our eyes and skin to blue light from technology, this light stimulus stimulates many cancers like, mammary cancers and skin cancers, , whereas blue light deprivation at night inhibits the carcinogenesis.  This is why I recommend blue blockers and clothing at night in artificially lit environments.   Epidemiological observations on increased risk of breast cancer in night shift workers, flight attendants, radio and telegraph operators and on decreased risk in blind women are in accordance with the results of experiments in rodents.

Treatment with pineal indole hormone melatonin inhibits carcinogenesis in pinealectomized rats or animals kept at the standard light/dark regimen (LD) or at the constant illumination (LL) regimen.  The physiology has been proven to happen in humans as well as the picture above illustrates. This is how many epithelial cancers like breast cancer and prostate cancer manifest.  In fact, most epithelial cancers come from altered light environments.  The proof is in the literature but no one in Big medicine and Big Pharma seem interested in the simple solutions I have been preaching for 1.5 decades now.  They want to keep everyone believing drugs and surgery remain the best idea for treating cancer.  It is impossible to patent sunlight, so this Rx is never presribed.  In fact, the sun has been vilified to drive profits from illness. 

When melanopsin damage occurs, vitamin A is liberated and this destroys the photoreceptors in the body that cause disease.  

UV light in the eye activates a chemical known as the melanocyte-stimulating hormone which makes the skin thicken and go brown to protect it from harmful rays.
Sunglasses block UV light from entering the pineal gland through the optic nerves in the eyes via the central retinal pathway I spoke about in my Vermont 2017 talk above. 

This prevents the brain from sending the signal to the pituitary gland to produce melanin, the pigment that tans the skin and protects it from burning. Excess Vitamin A in the blood also causes a reduction of melanin and lowers its photochemical abilities. This is why blue light and melanopsin dysfunction have been linked to many cancers. This was initially covered in ophthalmologist Fritz Hollwich's work from the 1940s as well. Also covered by Ott and Albert Schweitzer as seen below.

Here is the study below on sunglasses you might want to have a review before continuing your beliefs that they help you build wellness.   This belief is UNWISE in my opinion.  

Ultraviolet B Irradiation of the Eye Activates a Nitric Oxide-dependent Hypothalamopituitary Proopiomelanocortin Pathway and Modulates Functions of α-Melanocyte-stimulating Hormone-responsive Cells

This study clearly shows that localized UVB irradiation of the eye activates the hypothalamopituitary proopiomelanocortin (POMC) system via the iNOS-dependent neuronal network involving the first branch of the trigeminal nerves passing through the ciliary ganglia (parasympathetic ganglion located just behind the eye); therefore α-MSH-receptor containing cells are stimulated, such as DOPA-positive melanocytes in the skin. Given the high mutagenic activity of UVB, stimulation of the proliferation of, and of the synthesis of melanin pigments by epidermal melanocytes might play important parts in the protection of the underlying cells against UVB toxicity (Luger et al, 1998). Thus, the signaling pathway activated by UVB irradiation of the eye to increase plasma levels of α-MSH might function as ultra-sensitive mechanism by which UVB toxicity could be minimized in animals living in UV-enriched environment.

POMC (pictured above) is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core vesicles that are released from the cells by exocytosis in response to appropriate stimulation:

• α-MSH produced by neurons in the ventromedial nucleus has important roles in the regulation of appetite (POMC neuron stimulation results in satiety.) and sexual behavior, while α-MSH secreted from the intermediate lobe of the pituitary regulates the movement of melanin produced from melanocytes in skin.  This hormone is linked to the obesity epidemic humans currently face.  It also links it to infertility, and gender identity issues so common now.
• ACTH is a peptide hormone that regulates the secretion of glucocorticoids from the adrenal cortex.  This links to disorders linked to adrenal collapse like CFS/ME and Lyme and mold disease as well as electromagnetic hypersensitivity.
• β-Endorphin and [Met]enkephalin are endogenous opioid peptides with widespread actions in the brain.  This is where the current opiate crisis came from.  

WHAT WILL THE WISE NOW REALIZE?  

DON'T WEAR SUNGLASSES WHEN OUTSIDE! 

UVB is a needed part of the sun = MORE alpha-MSH = LESS DISEASE

The key point for the wise to realize is that solar UVB light is never present without IR-A and it is only present at certain precise times of the day tied to your location on the planet when blue light also has a specific color temperature that varies.  Using UV light without these boundary protective frequencies will always show a problem in the research.  This has benefited the dermatology and ophthalmology profits because it drives both eye disease and skin disease when you bury UV light from the sun from your life.  That is how the game is now played.  

UVB irradiation of the eye causes a positive local inflammation by stimulating nitric oxide (NO) to be produced as well as other inflammatory mediators from the vessels in the eye. This signaling molecule travels through the ciliary ganglia (parasympathetic ganglion located just behind the eye), which is the associated ganglia of the trigeminal nerve. This in turn activates the hypothalamopituitary proopiomelanocortin (POMC) system to do its thing in the eye and the central retinal pathways.

What is the above slide really saying? It says when UV light is present from the sun, Nature always wants Near infrared A  light there to replace the energy production in ATP function in the 600-1000nm range.  Sunlight always has this recipe.  UV light is NEVER found without NIR in Nature.  This is why this mechanism is built as it is.  It is also why use of UV light alone needs to be put in context.  

αlpha-Melanocyte-stimulating hormone (a-MSH) is cleaved from pro-opiomelanocortin (POMC) in the pituitary. Note: humans the skin is a more important source of the peptide. Skin pigmentation is therefore regulated by locally produced alpha-MSH rather than that of pituitary origin. Blue light stimulate alpha MSH more than any color in the visible spectrum.  This is why blue light is linked with obesity, cancer, and mitochondrial damage.  a-MSH is released into the plasma and DOPA positive melanocytes in the skin are stimulated.

Thus UVB radiation of the cornea and iris (UVB has weak penetration so does not readily pass to the retinal or beyond), may confers many down-stream benefits in tissues, beyond melanin production in melanocytes, via a-MSH. The proof that small amounts of UVB radiation does penetrate the anterior chamber of the eye is in the picture below.  This is not well known by most physicians globally.  They are taught that the anterior chamber blocks all UV light.  In 2009 when we found a UVA receptor called neuropsin on the cornea/skin this should have stimulated physicians to question these old beliefs but it has not.   

• Protection against UV-mediated DNA damage and the onset of oncogenesis is afforded by the tanning response in which UV irradiation triggers melanocytes to increase production of melanin that is then transferred to keratinocytes. Blue light does not stimulate melanin while UV does, and this is why blue light is associated with epithelial cancers and UV light is not.  The literature has missed this nuance.  A key component of the tanning process is the UV-mediated induction of the pro-opiomelanocortin (POMC) and MC1R genes encoding the alpha-melanocyte-stimulating hormone
• UV light decreases appetite/increases satiety = Leptin Rx
• Stimulates production of β-Endorphin and endogenous opioid peptides = reduces pain
• Better regulation of adrenal glucocorticoid hormones = lowers blood glucose
• α-MSH modulates the expression of Nrf2 and Nrf-dependent genes as a novel cytoprotective effector mechanism of this hormone. = decreases inflammation
• α-MSH suppresses TGF-β1-induced collagen synthesis by human dermal fibroblasts. transforming growth factor-β1 (TGF-β1),1 a multifunctional cytokine, is crucially involved in the pathogenesis of fibrotic disorders such as hypertrophic scars, keloids, localized scleroderma, systemic sclerosis, sclerodermic graft versus host disease of the skin, cirrhosis of the liver, and idiopathic induced lung fibrosis.  Red light augments these effects.
• 

• alpha-MSH has potent protective and antiinflammatory effects. At the molecular level, alpha-MSH affects various pathways implicated in regulation of inflammation and protection, i.e., nuclear factor-kappaB activation, expression of adhesion molecules and chemokine receptors, production of proinflammatory cytokines and mediators, IL-10 synthesis, T cell proliferation and activity, inflammatory cell migration, expression of antioxidative enzymes, and apoptosis.
• Realize that that Cold Thermogenesis 4-6 blogs all explain how alpha MSH links to leptin.  Leptin biology in turn operates via the central retinal pathways to be distributed all over the central nervous system to communicate energy balance throughout 
• The picture below should be self explanatory how many collateral effects are possible by wearing any tarps over your eyes.  Destruction of these photoreceptors lead to many diseases in modern humans.

SUMMARY:

Never cover your eyes from the sunlight they evolved to detect and regulate your hormones from sunrise to sunset. Diurnal animals also need darkness after sunset to release melatonin. Do cover your eyes and skin from artificial light at night? 

If not this is worse than wearing sunglasses during the day and why I recommend great blue blockers!  

Oxygen sensing by arterial chemoreceptors WHOLLY depends on mitochondrial complex I signaling = NAD+ levels.  

Sunglasses make the brain think it’s dark and this means you’re not starting the natural process of tanning.

As a result, you’re more likely to burn and therefore at more risk of skin cancer.  Light in the eye is an important factor in health.  the wrong frequency of light at the wrong time of day/night helps to short-circuit the body’s natural innate and adaptive defense mechanism against the sun.

It also puts you at risk for viral infections like C-19.  Imagine that.  

Light sculpts your life.  And sunglasses might be one of the key ways we get cancer.  A simple behavioral change might save your life.  How is it chiseling your marble today?

CITES:

https:. //www.sciencedirect.com/science/article/pii/S0022202X15301160

https://www.sciencedirect.com/science/article/pii/S1550413115004611

https://www.nature.com/articles/nature04284

https://iovs.arvojournals.org/article.aspx?articleid=2176699