HYPOXIA #10: HOW DOES C-19 LINK TO NAD+ DESTRUCTION?

Most people are not interested in learning what truth is. They would sooner sit in front of a box that continuously spits out lies and misinformation and entertains them. If that box emits blue light or nnEMF it might exacerbate an illness you have.  

Did you know that NAD+/NADH in cytochrome 1 is a fluorophore protein complex that transfers electrons in the electron transport chain of the inner mitochondrial membrane?

Fluorophores have particular importance in the field of biochemistry and protein studies. We use them in immunofluorescence studies. Fluorophores typically contain several combined aromatic groups, or plane or cyclic molecules with several π bonds. To understand them you need to know a bit of physics surrounding the photoelectric effect. The fluorophore absorbs light energy of a specific wavelength and re-emits light at a longer wavelength. The absorbed wavelengths, energy transfer efficiency, and time before emission depend on both the fluorophore structure and its chemical environment, as the molecule in its excited state interacts with surrounding molecules.

The best studied fluorophores in biology are nicotinamide adenine dinucleotides (NAD+/NADH). These proteins are small and all made out of nitrogen atoms. As I discussed in detail in Ubiquitination 17 blog post, NAD+ and sirtuins are designed to work together as a redox couple as well to create the eye’s clock timing mechanism.

Today’s humans have created a world and environment that is dominated by blue light emission and nnEMF night and day! Blue light and nnEMF destroys DHA presence in mammalian cell membranes everywhere in our tissues. Many other things also lower because of this effect. For example, Vitamin D levels go lower and this makes the Vitamin A levels in your blood to rise too. These two Vitamins are yoked to work. 

When this happens we see a redox shift in the NAD+/NADH couple of mitochondria. The destruction of this process (melanopsin) in the retina/skin/arteries however is the most important, because the eye clock controls the flow of carbon in every cell of our body. The flows of carbon are directly tied to how well our mitochondrial respiratory proteins work in concert with nuclear DNA. As DHA levels decline, the inputs to the SCN from melanopsin photoreceptors also decline. This degrades the optics of the atomic lattice in the SCN that responds to 460-550 nm light. This is in the blue/green range. This causes cells to age faster by raising their ubiquitin rates. Simultaneously it lowers NAD+ levels in cells.   

This is why I have told my clients that blueblocking glasses improve oxygenation and help boost immunity.  Most other experts have no idea how blue blockers are capable of this effect.  When oxygen tensions drop in the eye cataracts and acute macular degeneration are often the chronic effect.  This is how photoreceptor blindness occurs.

Melanopsin forms a functional photopigment capable of catalyzing G-protein activation in a light-dependent manner. This G-receptor needs DHA to function optimally. It is the melanopsin iRGC’s that generates melatonin rhythms in the pineal gland.

NAD+ causes a form of hypoxia. That hypoxia is seen in many diseases associated with acute and chronic mitochondrial failure. This is true in COVID 19, bacterial sepsis, diabetes, cancer. 

You've all seen this picture above in this series as it links to thiamine, lactate and pyruvate levels.  Now I need to make sure you see how it links to cytochrome 1 of your inner mitochondrial membrane.  When NAD+ is lowered pseudohypoxia predominates in cells.  

KEY POINT: As NAD+ lowers, so does the entire cell redox potential.  This selects for specific mitochondrial respiratory protein changes as they key factor in aging, heart disease, and oncogenesis. What are those changes? Normally the length of the respiratory chain in mitochondrial is 60 Angstroms. When NAD+ is lowered, the length increases. This alters how electrons can flow in electron chain transport and affect oxygen levels in cells.  Note below how this paper in the CITES wants to fool you into taking a supplement you don’t need if you just get natural terrestrial sunlight free daily.

Why did I tell members that Methylene blue might significantly help C-19 patients with hypoxia?   Methylene blue was once used to treat malaria.  This should peak your interests during this C-19 pandemic.  Methylene blue oxidizes NADH into NAD+, to replenish falling NAD+ levels due to the mitochondrial damage and increases the NAD+/NADH ratio as a result. They key most mitohacks using drugs and pills miss that it is not the ratio that matters most,  but the fact that the H in NADH comes from the TCA cycle intermediates  and it must be H+ form and not come from any trapped deuterium in the matrix.   

There are 3 layers to how life organizes that parallel the 3 legged stool, light, magnetism, and water chemistry. Why have I talked about pseudohypoxia for so long? Why have I told you to go back and read David Sinclair's Dec 2013 paper (CITES 2 below) on SIRT 1, HIF 1, and NAD+? 

These chemicals all link to every disease on this planet. Why? The liberation of oxygen from photosynthetic plants and bacteria also allowed more complex life forms to evolve using more complex energy transfers. These waste products of two kingdoms directly allowed DHA to form in the oceans 650 million years ago at the Cambrian explosion. The more complex things become morphologically in an organism as evolution has evolved, the more brain one needs to control all the circadian systems tied to the environment signals.  

SUMMARY

Hypoxia = low O2 = Low NAD+/NADH ratio = NAD+ drops in people with blue light exposure = elevated ubiquitin rates = low levels of electrons = electron density in tissues is a function of the DHA concentrations = low EZ size in cell water = dehydration = higher positive charges (protons) in proteins making them less hydrophilic = low intracellular pH = low redox potential = cell and mitochondrial swelling (cyto c release) = lowered magnetic and electric fields in mitochondria = low ATP levels = a lot of carbs and protein electrons on ECT = altered melatonin, serotonin and dopamine levels in the retina and frontal lobes = NT release tied to calcium efflux = calcium controls voltage gated channels, NMDA, and glutamate excitotoxicity= low DC electric current = low tissue DHA = altered perceptions of reality and depression/anxiety and just about any other disease you want to understand.

The data reveal the effects of lowered NAD + is due to loss of the circadian mechanism with aging and in most comorbid disease states through the spatiotemporal control of the molecular clock in cells. This is why the use of terrestrial sunlight is the best way to reset your molecular clock daily. Sunlight also decreases hypoxia risk in most diseases and this is why sunlight helps in all mitochondrial disease states. Today, we see the result of this in COVID-19 but the experts from the NIH still do not undertand the mechanism fully. That is why I decided to post this today.  It is also why using a supplement should be avoided as suggested in the paper below. This is why we should always seek the sunrise and sunset over manufactured pills. 

CITES: 

1. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30236-7#.XrCAABE4n-I.twitter

2.  https://www.cell.com/cell/fulltext/S0092-8674(13)01521-3