CPC #28 IS OBSTRUCTIVE SLEEP APNEA PROTECTIVE?

IS SLEEP APNEA PROTECTIVE AND NOT PATHOLOGIC?  

I believe the answer is yes.  Why do I say this?  

It appears sleep apnea protects defective mitochondria from high oxygen tensions. Want to know more watch my May 2018 webinar to understand the mitochondriac perspective.  I go further into detail in my August 2018 webinar that is being released today to my full members.  

This means it is really not a disease......it is a reaction to low NAD+ and high ROS made in mitochondria to control the flow of oxygen just as a carburetor does in a car.

Over-eating is going to stress the ECT.........that is ruined by the increased space between the cytochromes.......this implies oxygen levels have to be decreased when autophagy is ruined.  The biggest offender is blue light exposure via the eye and skin to cause this change in the melanopsin and Vitamin A couple.  Blue light exposure decouples Vitamin A and Vitamin D from one another as the slide below shows.

When ECT flow remains brisk and OSA is present,  oncogenic risks is higher.  Very few people with apnea seem to know that sleep apnea carries a pre-malignant risk with it because of this mitochondrial connection to defective apoptosis.

PREDICTION:  This is what I think is going to happen to Jimmy Moore and his fat laden diet married to his high technology appetite.  This lifestyle subtracts the sun because of his blue light addiction.  This ruins the melanopsin/retinol mechanism that is protective to the metabolic rate variations in uncoupling proteins.  These factors then lead to the key change in Kreb's bicycle slowing both cycles kinetics causing methionine to rise.

When that happens autophagy and apoptosis are broken and these things all follow: 

Cancer Changes:

1. that affect signaling of damage (the DNA damage response or DDR),
2. the extremely important WNT pathway that controls aspects of making RNA from DNA and especially proteins for apoptosis versus cell division. (The name WNT comes from pathways wingless in flies and int in mice)
3. enzymes called kinases that are part of vital pathways similar to WNT (MAPK, AKT),
4. the cytokine interferon that signals to the nucleus regulating and responding to making blood vessels, cell movement, defense against invasion, and cell death, and
5. inflammatory cytokines that stop apoptosis (nuclear factor-κB (NF-κB),

Cancer must inhibit apoptosis to occur. May 2018 webinar has it all laid out. Melanopsin optical signaling interruption in the eye and skin is capable of doing it ALL. The key feature in ALL CANCERS: ECT must be maintained while apoptosis inhibited.

OSA is a phenomenon that protects apoptosis from inactivation by keeping oxygen levels low. This protection scheme goes on until the deuterium entombment in the cell membranes of the PUFA's of the mitochondria overwhelm Kreb's bicycle and leads to COX-2 amplification.  This detail was covered in the May 2018 webinar and I went even deeper in the August 2018 webinar.  All cancers need high levels of oxygen to maintain high ECT speeds. The rising levels of methionine cause this.  This occurs because of the chronic slowing kinetics of the TCA and urea cycle eventually ruins the recycling of methionine from homocysteine.  This leads to blood vessels releasing angiogenesis factor to sprout new blood vessele to raise delievery of blood and oxygen.  Once this happens cancer is much more likely in a patient with OSA because it inhibits apoptosis.  

This happens because oxygen is highly electronegative on the periodic table and it draws electrons from NADH in cytochrome fast. Another way the electromagnetic force is utilized in cristae.  

Moreover,  sleep apnea sufferers struggle with spatial recognition and quantifying correct time.  This links it to a dopamine defect somewhere in the system.  This is also associated with a melanopsin defect in the eye or skin, as a result.  This implies sleep apnea is a protective effect cells use to buffer mitochondrial damage from melanopsin/retinol disruption.

Two things I carry with me daily: Death is certain, but life is not.
You pay the price of both, with your choices made daily around the electromagnetic spectrum.  You pay a biologic toll because of your choice, or you gain a biologic benefit because of your choice. At the outset, the dopamine levels are the same. After you decide and the results are in, you will see that the environment will add or subtract from your dopamine bank account.   The presence of time alteration and sleep apnea are two signs you better change what your are doing.  The result determines the reality you get. In this way, it should be clear how the environment dictates results we get.

AM sunlight balances the blue light of the morning.  Blue light power increases during the day while red light remains constant in sunlight.  

This implies blue light alerts us and is somehow related to time creation in the human brain.  

Blue light opens the optical windows of the skin and eyes via the melanopsin effect in arterioles to other portions of light in our environment.  When that is sunlight all is well.  When that light is all blue light and no UV or IR light sleep apnea is coming faster to your life.

What does this all imply?  Red light slows time. Cold slows time. Blue light creates and speds time perception up in the brain by altering the circadian clock functions.   UV light rebuilds and replenishes time in a complex dance that begins in your eyes and skin because of melanopsins effect on Vitamin A = retinol.  Therefore, excessive chronic blue light hazard speeds up time, the time mechanism in clock genes, and can give you mitochondrial diseases like cancer.  When you are blue light toxic your life is lived like a blue straggler star. Quick and bright.  Youre alert, and get sick quicker, and die sooner.  

AM sunlight is the light switch that creates the ideal level of dopamine and melatonin assuming your melanopsin system is working properly and OPERATIONAL.  The switch is tripped by what happens first in the eye and then the skin by the balance between dopamine and melatonin created by the days first light.  Many papers attribute bipolar dysfunction to the lateral habenula in the brain.  People with bi-polar disorder often have sleep apnea too and have altered time sensation.  This area has a lot of melanin in it and has melanopsin inputs to it as well.  This region of the human receives input from the stria medullaris thalami.  This region links the central retinal pathways and the SKIN to the hypothalamus. The stria medullaris is a part of the epi-thalamus. It is a fiber bundle containing afferent fibers from the septal nuclei, lateral pre-optic-hypothalamic region, and anterior thalamic nuclei that connect to the habenula.  The habenula sends many outputs to several midbrain regions involved in releasing neurotransmitters, such as dopamine, norepinephrine, and serotonin.

All of these chemicals are made from aromatic amino acids that need to be programmed by AM sunlight.  All three of these neurotransmitters are made initially in the eye and then the skin from sunlight and aromatic amino acids.  

Obstructive sleep apnea (OSA) patients show multiple neurobehavioral difficulties, including deficits in attention, psychomotor and executive functioning, memory, and affect (Beebe et al., 2003). However, the principal deficits in the syndrome involve the loss of motor control over the upper airway muscles, which fail to discharge in a timely fashion, when they should dilate the airway during diaphragmatic descent, and a loss of control over autonomic motor activity, with chronic, exaggerated sympathetic discharge from the PVN (Somers et al., 1995), and inappropriate lagged or muted dynamic sympathetic responses to blood pressure or ventilatory challenges.  This puts the problem in the brainstem in the dopamine tracts.   

The habenula regulates the activity of midbrain centers, including the dopaminergic ventral tegmental area (VTA).  This area is huge in Parkinson's disease development from melanopsin uncoupling on the surfaces of the eye and skin.  Phenylalanine and tyrosine can both be converted into these three neurotransmitters easily because both can make dopa. L-DOPA, is synthesized in the brain and kidneys of humans.  Look at the picture above where DOPA is made = tyrosine.   

Dopamine is also synthesized in plants and most animals. The brain includes several distinct dopamine pathways, one of which plays a major role in reward-motivated behavior. Most people do not even realize with a dopamine defect, control of blood glucose is lost too. This is why people with apnea often have diabetes.  

This becomes a key feature in the melanopsin damage seen in all forms of diabetes.  This one is best understood but researchers have done a poor job realizing how these pathways all begin with light signals in the retina/skin/blood vessels for proper physiologic functioning.  This is why bi-polar disease, diabetes, and parkinson's disease and SLEEP APNEA stump modern medicine.  

AM sunlight also stimulates POMC which makes beta-endorphin to make us seek AM light.  A lack of beta-endorphin sets up humans for an opiate crisis.  Modern humans have lost this GUIDING solar signal because of how they live their life and what light they live under most commonly.  Most types of rewards increase the level of dopamine in the brain.  In some diseases, like schizophrenia, too much dopamine at the wrong time ruins your ability to maintain cognition in time and space and leads to a crazy life.  This occurs in schizophrenia.  Without solar guidance, many modern humans seek opiate rewards in chemical ways to offset the deficit.  This leads many nights living humans to use many addictive drugs to increase dopamine neuronal activity to offset the loss of sunlight. Other brain dopamine pathways are involved in motor control and in controlling the release of various hormones.  These get damaged by chronic sunlight loss or too much blue light at the wrong time post sunset. It can even be a problem during the day if done chronically by a job and a computer screen or a phone to a teenager.  These pathways and cell groups form a dopamine system which is neuromodulatory and controlled by the circadian system by the melanopsin/retinol interactive controller.  This is the topic of my August 2018 webinar and it is why my Patrons are getting this blog right now at the same time.  Patrons it is time you sign up for your real Black Swan training here:  HYPERLINK  

Outside the central nervous system, dopamine functions primarily as a local chemical messenger and it needs the direction of sunlight.  How do we get light signals deep into the body this way?  Hemoglobin in the eye and skin is how it begins.  It is loaded with iron porphyrins which absorb 250 - 600 nm.  The water that surrounds it can absorb all the way to 3100nm.  

This light is ferried to cells to program the dopamine and melatonin release locally ot change the metabolic rate of mtDNA by altering the UCP2 permeability of deuterium.  The same is true of melatonin.   In blood vessels, dopamine inhibits norepinephrine release and acts as a vasodilator with Nitric oxide (UV-A);  melanopsin does the same thing using other frequencies of sunlight.   In the kidneys, dopamine increases sodium excretion and urine output;  This changes the EZ size in blood plasma.  In the pancreas, it reduces insulin production (diabetes link); in the digestive system, it reduces gastrointestinal motility and protects the intestinal mucosa gut barrier (leaky gut link); and in the immune system, it reduces the activity of lymphocytes which is important in autoimmunity.  

I said June 2, 2018 in Vermont that is not one human chronic disease not LINKED to the melanopsin/retinol mechanism.  Here is the slide I used. 

This post is a dip of the toe in why I might be correct in my reasoning.  With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it.  All of these link back to sunlight to the most fundamental level and no one but Black Swans realize it.  

The mitochondriac perspective always explains things we observe over the things modern medicine espouses. 

The more I study the history of intellectuals in medicine, the more they seem like a wrecking crew, dismantling civilization bit by bit — replacing what works in nature with what sounds good and repackaging it as evidence-based therapies.

Nothing replaces this..........and it is free. 

Start using it if you have sleep apnea because that symptom is your colony of mitochondria telling you there is a problem.

CITES:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930100/